What does the Organ-Specific Epigenetic Age Scores (TruHealth) test measure?

Why is Organ-Specific Epigenetic Age Scores (TruHealth) measured?

Organ-specific epigenetic age scores provide a granular biological ageing map that guides targeted organ-level preventive interventions. A patient with an overall PhenoAge within normal range but an accelerated liver epigenetic age may benefit from liver-targeted intervention (dietary modification, alcohol reduction, NAFLD management) beyond what systemic clock scores would indicate. Similarly, accelerated cardiac epigenetic age alongside normal lipid parameters may provide earlier signal of cardiovascular biological risk. TruHealth organ age scores should be interpreted as risk indicators that complement conventional organ-function laboratory markers (liver enzymes, eGFR, echocardiography) rather than replace them.

Reference ranges

Standard reference

Compared to chronological age — organ-specific biological age above chronological age indicates accelerated organ-level ageing in that system. # REVIEWER FLAG: Confirm which organ systems TruDiagnostic currently reports organ-specific epigenetic age for in the TruHealth report — published organ clock research covers liver, kidney, brain, heart, lung, and immune system among others. Confirm which are validated and currently included in TruDiagnostic's TruHealth output, and whether these are derived from Yang et al. organ clock methodology or a proprietary TruDiagnostic implementation.

Functional medicine optimal

All organ age scores ≤ chronological age; alignment with or below systemic PhenoAge is the longevity target per organ system. # REVIEWER FLAG: Confirm TruDiagnostic's organ age optimal framing, current organ list, and validation status for each organ clock in blood-derived methylation data.

Units

Years (biological age estimate per organ system)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.