What does the Immune Age (Epigenetic Immune Cell Composition and Immune Ageing Score) test measure?

Why is Immune Age (Epigenetic Immune Cell Composition and Immune Ageing Score) measured?

Immune ageing is a central driver of inflammaging — the chronic low-grade inflammatory state that accelerates age-related disease burden, reduces vaccine response, and impairs pathogen clearance. In functional medicine practice, an elevated immune age relative to chronological age contextualises inflammatory markers (hs-CRP, IL-6), immune function assessment, and vaccine response, and guides interventions targeting immune rejuvenation — including senolytic protocols, targeted nutrition, and exercise. The TruHealth immune age output situates the patient within the broader ageing landscape by revealing whether immune senescence is tracking ahead of or behind their overall biological age trajectory.

Reference ranges

Standard reference

Compared to chronological age-matched reference — below-average immune age indicates a biologically younger immune profile; above-average indicates immune ageing acceleration. # REVIEWER FLAG: Confirm TruDiagnostic's specific immune age scoring format, the immune cell types assessed via methylation deconvolution (typically CD8+ T cells, CD4+ T cells, NK cells, B cells, monocytes, granulocytes), and whether an immune age score or raw cell proportion estimates are reported in the TruHealth report.

Functional medicine optimal

Immune age ≤ chronological age; alignment with or below PhenoAge is the longevity target. # REVIEWER FLAG: Confirm TruDiagnostic's immune age optimal framing and reporting format.

Units

Score or years (platform-specific)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.