Biomarker Reference · B1
Intracellular Vitamin B1 (Thiamine) (B1) is a clinical biomarker used in comprehensive-panels assessment. Thiamine pyrophosphate is the active coenzyme for several mitochondrial enzymes in carbohydrate metabolism, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase. It is measured in 2 laboratory tests on BiomarkersLabs.com.
Thiamine pyrophosphate is the active coenzyme for several mitochondrial enzymes in carbohydrate metabolism, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase. Intracellular measurement in lymphocytes is intended to reflect tissue stores more closely than serum thiamine, which responds rapidly to recent intake and may not correlate with functional status.
Chronic thiamine insufficiency impairs oxidative metabolism and can present as fatigue, peripheral neuropathy, or cardiac dysfunction. Intracellular assay is positioned as a functional marker in patients with suspected subclinical deficiency despite normal serum levels, though evidence linking lymphocyte thiamine to clinical outcomes remains limited.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
2 tests on BiomarkersLabs.com include this biomarker.
Intracellular Vitamin B1 (Thiamine) reference range in this test: Laboratory-specific functional range based on lymphocyte extract.
Intracellular Vitamin B1 (Thiamine) reference range in this test: Laboratory-specific functional performance scale; typically reported as deficient/borderline/sufficient relative to stimulated lymphocyte growth.
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