Biomarker Reference · B12
Intracellular Vitamin B12 (Cobalamin) (B12) is a clinical biomarker used in comprehensive-panels assessment. Cobalamin is a cofactor for methionine synthase and methylmalonyl-CoA mutase, linking one-carbon metabolism, methylation, and propionate catabolism. It is measured in 2 laboratory tests on BiomarkersLabs.com.
Cobalamin is a cofactor for methionine synthase and methylmalonyl-CoA mutase, linking one-carbon metabolism, methylation, and propionate catabolism. Functional assays assess lymphocyte growth when cobalamin is rate-limiting, integrating absorption, transport, and intracellular conversion to active forms.
Vitamin B12 deficiency causes megaloblastic anaemia and subacute combined degeneration of the spinal cord. Intracellular assay is offered as an adjunct to serum B12 and methylmalonic acid in patients with borderline serum values or unexplained neurological symptoms, though its incremental diagnostic value over serum markers is debated.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
2 tests on BiomarkersLabs.com include this biomarker.
Intracellular Vitamin B12 (Cobalamin) reference range in this test: Laboratory-specific functional range.
Intracellular Vitamin B12 (Cobalamin) reference range in this test: Laboratory-specific functional performance scale.
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