What does the Ketone and Gluconeogenesis Markers test measure?

Why is Ketone and Gluconeogenesis Markers measured?

Urinary ketones confirm nutritional or pathological ketosis. The lactate:pyruvate ratio is an exploratory marker of mitochondrial function in functional medicine. Persistent ketonuria in a non-fasting, non-ketogenic individual warrants evaluation for diabetes or an inborn error of metabolism.

Reference ranges

Standard reference

Laboratory-specific ranges; beta-hydroxybutyrate typically undetectable or trace in a fed state

Functional medicine optimal

Functional interpretation is context-dependent: ketones are expected and beneficial in ketogenic or fasting states, abnormal otherwise. Lactate elevation is assessed relative to pyruvate.

Units

mmol/mol creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.