Which tests measure Neurotransmitter Metabolites?

Neurotransmitter Metabolites is measured in 1 test on BiomarkersLabs.com, including 62 Organic Acids Profile.

Biomarker Reference · HVA, VMA, 5-HIAA, DOPAC

What does the Neurotransmitter Metabolites test measure?

Q: What is the reference range for Neurotransmitter Metabolites?

The standard reference range for Neurotransmitter Metabolites is Laboratory-specific ranges for homovanillate (HVA), vanillylmandelate (VMA), 5-hydroxyindoleacetate (5-HIAA), 3,4-dihydroxyphenylacetate (DOPAC). Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Neurotransmitter Metabolites (HVA, VMA, 5-HIAA, DOPAC) is a clinical biomarker used in comprehensive-panels assessment. Homovanillate is the principal urinary metabolite of dopamine, vanillylmandelate of noradrenaline and adrenaline, and 5-hydroxyindoleacetate of serotonin. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory-specific ranges for homovanillate (HVA), vanillylmandelate (VMA), 5-hydroxyindoleacetate (5-HIAA), 3,4-dihydroxyphenylacetate (DOPAC)
Units: mmol/mol creatinine
Measured In: 1 test
Category: —

Functional medicine optimalFunctional optimal ranges are narrower than laboratory reference limits and are assay-dependent; interpret cautiously and within clinical context.

What is Neurotransmitter Metabolites?

Homovanillate is the principal urinary metabolite of dopamine, vanillylmandelate of noradrenaline and adrenaline, and 5-hydroxyindoleacetate of serotonin. These metabolites reflect whole-body turnover of monoamine neurotransmitters, influenced by synthesis rate, synaptic activity, and enzymatic degradation by monoamine oxidase and catechol-O-methyltransferase.

Why is Neurotransmitter Metabolites measured?

Urinary neurotransmitter metabolites are used in functional practice to infer monoamine status and guide amino-acid or cofactor interventions. Low HVA or 5-HIAA may suggest inadequate precursor supply or cofactor deficiency, while very high VMA can reflect sympathetic activation or, rarely, catecholamine-secreting tumours. These are screening-level markers, not diagnostic for primary neuropsychiatric or neuroendocrine disease.

Reference ranges

Standard reference: Laboratory-specific ranges for homovanillate (HVA), vanillylmandelate (VMA), 5-hydroxyindoleacetate (5-HIAA), 3,4-dihydroxyphenylacetate (DOPAC)
Functional medicine optimal: Functional optimal ranges are narrower than laboratory reference limits and are assay-dependent; interpret cautiously and within clinical context.
Units: mmol/mol creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Neurotransmitter Metabolites

1 test on BiomarkersLabs.com include this biomarker.

BML-CHP-008Comprehensive

62 Organic Acids Profile

Neurotransmitter Metabolites reference range in this test: Laboratory-specific ranges for homovanillate (HVA), vanillylmandelate (VMA), 5-hydroxyindoleacetate (5-HIAA), 3,4-dihydroxyphenylacetate (DOPAC)

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Mitochondrial Energy Metabolism MarkersCitric acid cycle intermediates1 test Gut Microbial MetabolitesDysbiosis markers1 test Yeast and Fungal MetabolitesCandida markers1 test Oxalate MetabolismOxalate, glycolate, glycerate1 test Vitamin and Cofactor MarkersMethylmalonate, formiminoglutamate, kynurenate, xanthurenate, pyridoxate1 test Fatty Acid Oxidation MarkersAdipate, suberate, sebacate, ethylmalonate1 test Ketone and Gluconeogenesis MarkersBeta-hydroxybutyrate, acetoacetate, pyruvate, lactate1 test Detoxification and Phase II MarkersGlucarate, sulfate, pyroglutamate, orotate1 test

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