What is the reference range for Vitamin and Cofactor Markers?

The standard reference range for Vitamin and Cofactor Markers is Laboratory-specific functional ranges. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Vitamin and Cofactor Markers?

Vitamin and Cofactor Markers is measured in 1 test on BiomarkersLabs.com, including 62 Organic Acids Profile.

Biomarker Reference · Methylmalonate, formiminoglutamate, kynurenate, xanthurenate, pyridoxate

What does the Vitamin and Cofactor Markers test measure?

Vitamin and Cofactor Markers (Methylmalonate, formiminoglutamate, kynurenate, xanthurenate, pyridoxate) is a clinical biomarker used in comprehensive-panels assessment. Methylmalonate accumulates when vitamin B12 or the adenosylcobalamin cofactor is insufficient for methylmalonyl-CoA mutase. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory-specific functional ranges
Units: mmol/mol creatinine
Measured In: 1 test
Category: —

Functional medicine optimalFunctional optimal ranges are tighter than reference limits and are used to detect subclinical deficiency before overt clinical manifestations.

What is Vitamin and Cofactor Markers?

Methylmalonate accumulates when vitamin B12 or the adenosylcobalamin cofactor is insufficient for methylmalonyl-CoA mutase. Formiminoglutamate (FIGLU) accumulates in folate deficiency, when formimino transfer to tetrahydrofolate is impaired. Kynurenate and xanthurenate are tryptophan metabolites elevated in vitamin B6 deficiency, which impairs kynureninase and kynurenine aminotransferase. Pyridoxate is a urinary form of vitamin B6.

Why is Vitamin and Cofactor Markers measured?

Organic-acid assessment of vitamin status complements serum micronutrient testing by revealing functional intracellular deficiency. Elevated methylmalonate prompts B12 repletion; elevated FIGLU suggests folate insufficiency; elevated kynurenate and xanthurenate indicate B6 deficiency. These markers guide targeted supplementation in functional and integrative practice.

Reference ranges

Standard reference: Laboratory-specific functional ranges
Functional medicine optimal: Functional optimal ranges are tighter than reference limits and are used to detect subclinical deficiency before overt clinical manifestations.
Units: mmol/mol creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Vitamin and Cofactor Markers

1 test on BiomarkersLabs.com include this biomarker.

BML-CHP-008Comprehensive

62 Organic Acids Profile

Vitamin and Cofactor Markers reference range in this test: Laboratory-specific functional ranges

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Mitochondrial Energy Metabolism MarkersCitric acid cycle intermediates1 test Neurotransmitter MetabolitesHVA, VMA, 5-HIAA, DOPAC1 test Gut Microbial MetabolitesDysbiosis markers1 test Yeast and Fungal MetabolitesCandida markers1 test Oxalate MetabolismOxalate, glycolate, glycerate1 test Fatty Acid Oxidation MarkersAdipate, suberate, sebacate, ethylmalonate1 test Ketone and Gluconeogenesis MarkersBeta-hydroxybutyrate, acetoacetate, pyruvate, lactate1 test Detoxification and Phase II MarkersGlucarate, sulfate, pyroglutamate, orotate1 test

Order tests measuring Vitamin and Cofactor Markers for your patients

Available exclusively to verified licensed healthcare practitioners. CLIA-certified laboratory results delivered to your secure portal.

Create Free Account