What is the reference range for Methylation Capacity Index?

The standard reference range for Methylation Capacity Index is Laboratory-specific; derived from genotype combinations and biochemical context. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Methylation Capacity Index?

Methylation Capacity Index is measured in 1 test on BiomarkersLabs.com, including Add-On CNA + MethylDetox Profile.

Biomarker Reference · MCI

What does the Methylation Capacity Index test measure?

Methylation Capacity Index (MCI) is a clinical biomarker used in comprehensive-panels assessment. A composite or algorithmic score that integrates MTHFR, MTR, MTRR, and other genotypes to estimate net one-carbon/methylation flux. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory-specific; derived from genotype combinations and biochemical context
Units: composite score
Measured In: 1 test
Category: —

Functional medicine optimalLaboratory defines tiers (low, intermediate, high capacity); optimal is context-dependent and individualised.

What is Methylation Capacity Index?

A composite or algorithmic score that integrates MTHFR, MTR, MTRR, and other genotypes to estimate net one-carbon/methylation flux. The index is proprietary to the performing laboratory and reflects predicted capacity to generate S-adenosylmethionine and maintain homocysteine clearance under typical dietary conditions.

Why is Methylation Capacity Index measured?

Used as a personalised functional-medicine tool to guide methylated-vitamin formulations (methylfolate, methylcobalamin, trimethylglycine) and to interpret plasma homocysteine or methylmalonic acid in genetic context. The score is not validated as a standalone diagnostic marker, and clinical utility depends on integration with biochemical measures and symptoms.

Reference ranges

Standard reference: Laboratory-specific; derived from genotype combinations and biochemical context
Functional medicine optimal: Laboratory defines tiers (low, intermediate, high capacity); optimal is context-dependent and individualised.
Units: composite score

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Methylation Capacity Index

1 test on BiomarkersLabs.com include this biomarker.

BML-CHP-012Comprehensive

Add-On CNA + MethylDetox Profile

Methylation Capacity Index reference range in this test: Laboratory-specific; derived from genotype combinations and biochemical context

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Methylenetetrahydrofolate Reductase C677T PolymorphismMTHFR C677T3 tests Methylenetetrahydrofolate Reductase A1298C PolymorphismMTHFR A1298C3 tests Catechol-O-Methyltransferase V158M PolymorphismCOMT V158M2 tests Methionine Synthase A2756G PolymorphismMTR A2756G1 test Methionine Synthase Reductase A66G PolymorphismMTRR A66G1 test Cystathionine Beta-Synthase C699T PolymorphismCBS C699T1 test

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