What is the reference range for Methionine Synthase Reductase A66G Polymorphism?

The standard reference range for Methionine Synthase Reductase A66G Polymorphism is Wild-type (AA), heterozygous (AG), homozygous variant (GG). Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Biomarker Reference · MTRR A66G

What does the Methionine Synthase Reductase A66G Polymorphism test measure?

Q: Which tests measure Methionine Synthase Reductase A66G Polymorphism?

Methionine Synthase Reductase A66G Polymorphism is measured in 1 test on BiomarkersLabs.com, including Add-On CNA + MethylDetox Profile.

Methionine Synthase Reductase A66G Polymorphism (MTRR A66G) is a clinical biomarker used in comprehensive-panels assessment. Methionine synthase reductase regenerates the active form of methionine synthase by reductive methylation of its cobalamin cofactor. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Wild-type (AA), heterozygous (AG), homozygous variant (GG)
Units: genotype
Measured In: 1 test
Category: —

Functional medicine optimalNot applicable; genotype is static and forms part of a multi-gene methylation assessment.

What is Methionine Synthase Reductase A66G Polymorphism?

Methionine synthase reductase regenerates the active form of methionine synthase by reductive methylation of its cobalamin cofactor. The A66G polymorphism may alter reductase efficiency, influencing the rate at which methionine synthase is restored to active service and thereby affecting one-carbon metabolism under conditions of oxidative stress or suboptimal B12.

Why is Methionine Synthase Reductase A66G Polymorphism measured?

The GG genotype has been associated with altered homocysteine and differential response to B12 supplementation in some populations. Functional medicine protocols use MTRR genotype alongside MTR and MTHFR to tailor methylated B-vitamin formulations, though the independent clinical impact of MTRR A66G is modest and context-dependent.

Reference ranges

Standard reference: Wild-type (AA), heterozygous (AG), homozygous variant (GG)
Functional medicine optimal: Not applicable; genotype is static and forms part of a multi-gene methylation assessment.
Units: genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Methionine Synthase Reductase A66G Polymorphism

1 test on BiomarkersLabs.com include this biomarker.

BML-CHP-012Comprehensive

Add-On CNA + MethylDetox Profile

Methionine Synthase Reductase A66G Polymorphism reference range in this test: Wild-type (AA), heterozygous (AG), homozygous variant (GG)

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Methylenetetrahydrofolate Reductase C677T PolymorphismMTHFR C677T3 tests Methylenetetrahydrofolate Reductase A1298C PolymorphismMTHFR A1298C3 tests Catechol-O-Methyltransferase V158M PolymorphismCOMT V158M2 tests Methionine Synthase A2756G PolymorphismMTR A2756G1 test Cystathionine Beta-Synthase C699T PolymorphismCBS C699T1 test Methylation Capacity IndexMCI1 test

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