What is the reference range for Methionine Synthase A2756G Polymorphism?

The standard reference range for Methionine Synthase A2756G Polymorphism is Wild-type (AA), heterozygous (AG), homozygous variant (GG). Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Methionine Synthase A2756G Polymorphism?

Methionine Synthase A2756G Polymorphism is measured in 1 test on BiomarkersLabs.com, including Add-On CNA + MethylDetox Profile.

Biomarker Reference · MTR A2756G

What does the Methionine Synthase A2756G Polymorphism test measure?

Methionine Synthase A2756G Polymorphism (MTR A2756G) is a clinical biomarker used in comprehensive-panels assessment. Methionine synthase catalyses the remethylation of homocysteine to methionine, using 5-methyltetrahydrofolate as the methyl donor and vitamin B12 (methylcobalamin) as a cofactor. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Wild-type (AA), heterozygous (AG), homozygous variant (GG)
Units: genotype
Measured In: 1 test
Category: —

Functional medicine optimalNot applicable; genotype is reported as present or absent and interpreted in context of B12 and folate biochemistry.

What is Methionine Synthase A2756G Polymorphism?

Methionine synthase catalyses the remethylation of homocysteine to methionine, using 5-methyltetrahydrofolate as the methyl donor and vitamin B12 (methylcobalamin) as a cofactor. The A2756G polymorphism may affect enzyme-substrate interaction or stability. Functional activity depends on adequate B12 and folate status, so genetic variation interacts with nutritional sufficiency.

Why is Methionine Synthase A2756G Polymorphism measured?

Variants at MTR A2756G have been associated with altered homocysteine and methionine in some studies, particularly when B12 status is marginal. Functional practitioners interpret this genotype as part of a broader methylation map, guiding methylcobalamin and methylfolate dosing, though evidence for clinical utility is less robust than for MTHFR C677T.

Reference ranges

Standard reference: Wild-type (AA), heterozygous (AG), homozygous variant (GG)
Functional medicine optimal: Not applicable; genotype is reported as present or absent and interpreted in context of B12 and folate biochemistry.
Units: genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Methionine Synthase A2756G Polymorphism

1 test on BiomarkersLabs.com include this biomarker.

BML-CHP-012Comprehensive

Add-On CNA + MethylDetox Profile

Methionine Synthase A2756G Polymorphism reference range in this test: Wild-type (AA), heterozygous (AG), homozygous variant (GG)

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Methylenetetrahydrofolate Reductase C677T PolymorphismMTHFR C677T3 tests Methylenetetrahydrofolate Reductase A1298C PolymorphismMTHFR A1298C3 tests Catechol-O-Methyltransferase V158M PolymorphismCOMT V158M2 tests Methionine Synthase Reductase A66G PolymorphismMTRR A66G1 test Cystathionine Beta-Synthase C699T PolymorphismCBS C699T1 test Methylation Capacity IndexMCI1 test

Order tests measuring Methionine Synthase A2756G Polymorphism for your patients

Available exclusively to verified licensed healthcare practitioners. CLIA-certified laboratory results delivered to your secure portal.