What is the reference range for 4-Hydroxyestrone (dried urine, GCMS)?

The standard reference range for 4-Hydroxyestrone (dried urine, GCMS) is Typically lower than 2-OHE1; laboratory-specific intervals.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure 4-Hydroxyestrone (dried urine, GCMS)?

4-Hydroxyestrone (dried urine, GCMS) is measured in 1 test on BiomarkersLabs.com, including Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites.

Biomarker Reference · 4-OHE1

What does the 4-Hydroxyestrone (dried urine, GCMS) test measure?

4-Hydroxyestrone (dried urine, GCMS) (4-OHE1) is a clinical biomarker used in thyroid-endocrine assessment. 4-Hydroxyestrone is generated by CYP1B1 hydroxylation at the C-4 position. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Typically lower than 2-OHE1; laboratory-specific intervals.
Units: ng/mg creatinine
Measured In: 1 test
Category: Thyroid

Functional medicine optimalLower relative to 2-OHE1 is generally preferred in functional interpretation.

What is 4-Hydroxyestrone (dried urine, GCMS)?

4-Hydroxyestrone is generated by CYP1B1 hydroxylation at the C-4 position. It retains oestrogenic activity and, unlike 2-hydroxy metabolites, can undergo redox cycling to form semiquinones and quinones that react with DNA to produce depurinating adducts.

Why is 4-Hydroxyestrone (dried urine, GCMS) measured?

Elevated 4-OHE1 has been associated in mechanistic studies with increased oxidative DNA damage and is hypothesised to contribute to oestrogen-related carcinogenesis. Some practitioners use the 4:2 hydroxy ratio as a marker of 'unfavourable' metabolism, though clinical outcome data linking ratios to cancer incidence remain inconclusive.

Reference ranges

Standard reference: Typically lower than 2-OHE1; laboratory-specific intervals.
Functional medicine optimal: Lower relative to 2-OHE1 is generally preferred in functional interpretation.
Units: ng/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure 4-Hydroxyestrone (dried urine, GCMS)

1 test on BiomarkersLabs.com include this biomarker.

BML-THY-032Comprehensive

Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites

4-Hydroxyestrone (dried urine, GCMS) reference range in this test: Typically lower than 2-OHE1; laboratory-specific intervals.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Thyroid-Stimulating HormoneTSH5 tests Free ThyroxineFT45 tests Free TriiodothyronineFT35 tests Thyroid Peroxidase Antibodies (dried blood spot)TPOAb3 tests Estrone (dried urine, GCMS)E11 test Estradiol (dried urine, GCMS)E21 test Estriol (dried urine, GCMS)E31 test 2-Hydroxyestrone (dried urine, GCMS)2-OHE11 test

Order tests measuring 4-Hydroxyestrone (dried urine, GCMS) for your patients

Available exclusively to verified licensed healthcare practitioners. CLIA-certified laboratory results delivered to your secure portal.