What is Anti-CBir1 Flagellin IgG?
CBir1 is a bacterial flagellin derived from commensal gut flora. Antibodies to CBir1 are markers of a loss of tolerance to flagellated intestinal bacteria and are seen predominantly in Crohn's disease, correlating with complicated, fibrostenotic, and perforating phenotypes. The presence of anti-CBir1 antibodies implies that bacterial antigens drive part of the mucosal immune response in susceptible individuals.