What is the reference range for Anti-Tissue Transglutaminase IgA?

The standard reference range for Anti-Tissue Transglutaminase IgA is 30 U/mL positive.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Anti-Tissue Transglutaminase IgA?

Anti-Tissue Transglutaminase IgA is measured in 1 test on BiomarkersLabs.com, including Add-On Celiac, IBS, and Crohn's Assay (CICA).

Biomarker Reference · anti-tTG IgA

What does the Anti-Tissue Transglutaminase IgA test measure?

Q: Why is Anti-Tissue Transglutaminase IgA measured?

IgA anti-tTG is the single most sensitive and specific serological marker of coeliac disease in immunocompetent patients. A strongly positive result in a patient with compatible symptoms and HLA-DQ2 or HLA-DQ8 may permit diagnosis without initial biopsy in selected paediatric cases, though biopsy remains the reference standard in adults.

Anti-Tissue Transglutaminase IgA (anti-tTG IgA) is a clinical biomarker used in gastrointestinal assessment. IgA antibodies to tissue transglutaminase are the dominant immunoglobulin class in the coeliac immune response. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <20 U/mL negative; 20–30 U/mL equivocal; >30 U/mL positive.
Units: U/mL
Measured In: 1 test
Category: Gastrointestinal

Functional medicine optimalNegative (<20 U/mL) in the absence of coeliac disease and on a gluten-containing diet.

What is Anti-Tissue Transglutaminase IgA?

IgA antibodies to tissue transglutaminase are the dominant immunoglobulin class in the coeliac immune response. They are produced by plasma cells in the intestinal mucosa and appear in serum when gluten exposure is ongoing. IgA anti-tTG correlates closely with the degree of villous atrophy and falls on a gluten-free diet, making it the cornerstone of both diagnosis and monitoring.

Why is Anti-Tissue Transglutaminase IgA measured?

IgA anti-tTG is the single most sensitive and specific serological marker of coeliac disease in immunocompetent patients. A strongly positive result in a patient with compatible symptoms and HLA-DQ2 or HLA-DQ8 may permit diagnosis without initial biopsy in selected paediatric cases, though biopsy remains the reference standard in adults.

Reference ranges

Standard reference: <20 U/mL negative; 20–30 U/mL equivocal; >30 U/mL positive.
Functional medicine optimal: Negative (<20 U/mL) in the absence of coeliac disease and on a gluten-containing diet.
Units: U/mL

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-Tissue Transglutaminase IgA

1 test on BiomarkersLabs.com include this biomarker.

BML-GAS-053Comprehensive

Add-On Celiac, IBS, and Crohn's Assay (CICA)

Anti-Tissue Transglutaminase IgA reference range in this test: <20 U/mL negative; 20–30 U/mL equivocal; >30 U/mL positive.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Tissue Transglutaminase IgGanti-tTG IgG1 test Anti-Saccharomyces cerevisiae IgGASCA IgG1 test Anti-Saccharomyces cerevisiae IgAASCA IgA1 test Anti-CBir1 Flagellin IgGanti-CBir11 test

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