Biomarker Reference · ASCA IgG
Anti-Saccharomyces cerevisiae IgG (ASCA IgG) is a clinical biomarker used in gastrointestinal assessment. Saccharomyces cerevisiae is baker's and brewer's yeast; antibodies to its cell-wall mannans are markers of an aberrant mucosal immune response to commensal and dietary fungi. It is measured in 1 laboratory test on BiomarkersLabs.com.
Saccharomyces cerevisiae is baker's and brewer's yeast; antibodies to its cell-wall mannans are markers of an aberrant mucosal immune response to commensal and dietary fungi. ASCA IgG and IgA appear more frequently in Crohn's disease than in ulcerative colitis or healthy controls, though the antigenic trigger and pathogenic role remain incompletely understood.
ASCA positivity (IgG or IgA, or both) is seen in roughly half of Crohn's disease patients and is more specific for Crohn's than for ulcerative colitis. When combined with perinuclear anti-neutrophil cytoplasmic antibodies (pANCA) — typically positive in ulcerative colitis and negative in Crohn's — serology can support differentiation of inflammatory bowel disease subtypes, though endoscopy and histology remain definitive.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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