What is the reference range for Anti-Tissue Transglutaminase IgG?

The standard reference range for Anti-Tissue Transglutaminase IgG is 30 U/mL positive.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Anti-Tissue Transglutaminase IgG?

Anti-Tissue Transglutaminase IgG is measured in 1 test on BiomarkersLabs.com, including Add-On Celiac, IBS, and Crohn's Assay (CICA).

Biomarker Reference · anti-tTG IgG

What does the Anti-Tissue Transglutaminase IgG test measure?

Q: Why is Anti-Tissue Transglutaminase IgG measured?

IgG anti-tTG is a second-line coeliac serology when IgA testing is unavailable or the patient has confirmed IgA deficiency. Its sensitivity and specificity are lower than IgA anti-tTG, so it supplements rather than replaces standard serology in most cases.

Anti-Tissue Transglutaminase IgG (anti-tTG IgG) is a clinical biomarker used in gastrointestinal assessment. Tissue transglutaminase is an enzyme that deamidates gliadin peptides in the intestinal lamina propria. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <20 U/mL negative; 20–30 U/mL equivocal; >30 U/mL positive.
Units: U/mL
Measured In: 1 test
Category: Gastrointestinal

Functional medicine optimalNegative (<20 U/mL) in the absence of coeliac disease and on a gluten-containing diet.

What is Anti-Tissue Transglutaminase IgG?

Tissue transglutaminase is an enzyme that deamidates gliadin peptides in the intestinal lamina propria. In coeliac disease, these modified peptides bind HLA-DQ2 or HLA-DQ8 on antigen-presenting cells, triggering a T-cell response and production of IgG and IgA antibodies against tissue transglutaminase itself. IgG anti-tTG antibodies are measured primarily in patients with selective IgA deficiency, who cannot mount an IgA anti-tTG response.

Why is Anti-Tissue Transglutaminase IgG measured?

IgG anti-tTG is a second-line coeliac serology when IgA testing is unavailable or the patient has confirmed IgA deficiency. Its sensitivity and specificity are lower than IgA anti-tTG, so it supplements rather than replaces standard serology in most cases.

Reference ranges

Standard reference: <20 U/mL negative; 20–30 U/mL equivocal; >30 U/mL positive.
Functional medicine optimal: Negative (<20 U/mL) in the absence of coeliac disease and on a gluten-containing diet.
Units: U/mL

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-Tissue Transglutaminase IgG

1 test on BiomarkersLabs.com include this biomarker.

BML-GAS-053Comprehensive

Add-On Celiac, IBS, and Crohn's Assay (CICA)

Anti-Tissue Transglutaminase IgG reference range in this test: <20 U/mL negative; 20–30 U/mL equivocal; >30 U/mL positive.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Tissue Transglutaminase IgAanti-tTG IgA1 test Anti-Saccharomyces cerevisiae IgGASCA IgG1 test Anti-Saccharomyces cerevisiae IgAASCA IgA1 test Anti-CBir1 Flagellin IgGanti-CBir11 test

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