What is Anti-Centromere Antibody?
Centromere proteins (CENP-A, -B, -C) are kinetochore components essential for chromosome segregation. Anti-centromere antibodies produce a discrete speckled pattern on metaphase cells in immunofluorescence.
Biomarker Reference · ACA
Anti-Centromere Antibody (ACA) is a clinical biomarker used in autoimmune-inflammation assessment. Centromere proteins (CENP-A, -B, -C) are kinetochore components essential for chromosome segregation. It is measured in 1 laboratory test on BiomarkersLabs.com.
Centromere proteins (CENP-A, -B, -C) are kinetochore components essential for chromosome segregation. Anti-centromere antibodies produce a discrete speckled pattern on metaphase cells in immunofluorescence.
Anti-centromere is the hallmark of limited cutaneous systemic sclerosis (CREST syndrome) and primary biliary cholangitis. It predicts a lower risk of severe internal organ involvement compared with anti-Scl-70, though pulmonary arterial hypertension remains a concern in long-standing disease.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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