Biomarker Reference · Anti-Sm
Anti-Smith Antibody (Anti-Sm) is a clinical biomarker used in autoimmune-inflammation assessment. Smith antigen is a core component of small nuclear ribonucleoprotein particles involved in mRNA splicing. It is measured in 1 laboratory test on BiomarkersLabs.com.
Smith antigen is a core component of small nuclear ribonucleoprotein particles involved in mRNA splicing. Anti-Sm antibodies are directed against these proteins and are found almost exclusively in systemic lupus erythematosus, though their pathogenic role remains uncertain.
Anti-Sm is one of the most specific antibodies for SLE (>95 per cent specificity) and is an ACR/EULAR classification criterion. However, it is present in only 10–30 per cent of patients with lupus, limiting its sensitivity. Unlike anti-dsDNA, anti-Sm titres do not correlate well with disease activity.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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