Biomarker Reference · HOMA-IR
Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) is a clinical biomarker used in metabolic-diabetes assessment. HOMA-IR is a calculated index derived from fasting glucose and fasting insulin using the formula (glucose [mg/dL] × insulin [µU/mL]) / 405. It is measured in 2 laboratory tests on BiomarkersLabs.com.
HOMA-IR is a calculated index derived from fasting glucose and fasting insulin using the formula (glucose [mg/dL] × insulin [µU/mL]) / 405. It models the feedback loop between beta-cell insulin secretion and hepatic glucose production, providing a surrogate for clamp-measured insulin sensitivity. Higher values indicate greater resistance.
HOMA-IR quantifies insulin resistance in research and clinical practice, bridging the gap between simple fasting glucose and the gold-standard hyperinsulinaemic-euglycaemic clamp. It is widely used to screen for and track insulin resistance in metabolic syndrome, PCOS, and MASLD, and values above 2.0–2.5 are typically considered insulin-resistant depending on the population.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
2 tests on BiomarkersLabs.com include this biomarker.
Homeostatic Model Assessment of Insulin Resistance reference range in this test: <2.0; varies by population and assay.
Homeostatic Model Assessment of Insulin Resistance reference range in this test: <2.0 (insulin-sensitive), >2.5 (insulin-resistant); population-specific
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