What is the reference range for High-Sensitivity C-Reactive Protein?

The standard reference range for High-Sensitivity C-Reactive Protein is 3.0 mg/L high risk (AHA/CDC for cardiovascular risk).. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure High-Sensitivity C-Reactive Protein?

High-Sensitivity C-Reactive Protein is measured in 1 test on BiomarkersLabs.com, including Advanced Metabolic Panel.

Biomarker Reference · hs-CRP

What does the High-Sensitivity C-Reactive Protein test measure?

Q: Why is High-Sensitivity C-Reactive Protein measured?

hs-CRP is a non-specific marker of systemic inflammation used for cardiovascular risk stratification independent of lipid levels, obesity, and metabolic syndrome. Persistently elevated hs-CRP predicts future myocardial infarction and stroke, and trending CRP helps monitor inflammatory conditions such as autoimmune disease. Very high values (>10 mg/L) suggest acute infection or inflammation and should prompt further investigation rather than cardiovascular risk interpretation.

High-Sensitivity C-Reactive Protein (hs-CRP) is a clinical biomarker used in metabolic-diabetes assessment. C-reactive protein is an acute-phase reactant synthesised by hepatocytes in response to interleukin-6 and other inflammatory cytokines. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <1.0 mg/L low risk; 1.0–3.0 mg/L moderate risk; >3.0 mg/L high risk (AHA/CDC for cardiovascular risk).
Units: mg/L
Measured In: 1 test
Category: Metabolic

Functional medicine optimalFor cardiovascular risk, <1.0 mg/L is considered low risk; metabolic-health practitioners often target levels below 0.5–1.0 mg/L.

What is High-Sensitivity C-Reactive Protein?

C-reactive protein is an acute-phase reactant synthesised by hepatocytes in response to interleukin-6 and other inflammatory cytokines. High-sensitivity assays measure CRP at concentrations well below the range of traditional inflammation assays, enabling stratification of low-grade chronic inflammation. CRP rises rapidly in acute infection or tissue injury and falls as inflammation resolves.

Why is High-Sensitivity C-Reactive Protein measured?

hs-CRP is a non-specific marker of systemic inflammation used for cardiovascular risk stratification independent of lipid levels, obesity, and metabolic syndrome. Persistently elevated hs-CRP predicts future myocardial infarction and stroke, and trending CRP helps monitor inflammatory conditions such as autoimmune disease. Very high values (>10 mg/L) suggest acute infection or inflammation and should prompt further investigation rather than cardiovascular risk interpretation.

Reference ranges

Standard reference: <1.0 mg/L low risk; 1.0–3.0 mg/L moderate risk; >3.0 mg/L high risk (AHA/CDC for cardiovascular risk).
Functional medicine optimal: For cardiovascular risk, <1.0 mg/L is considered low risk; metabolic-health practitioners often target levels below 0.5–1.0 mg/L.
Units: mg/L

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure High-Sensitivity C-Reactive Protein

1 test on BiomarkersLabs.com include this biomarker.

BML-MET-018Comprehensive

Advanced Metabolic Panel

High-Sensitivity C-Reactive Protein reference range in this test: <1.0 mg/L low risk; 1.0–3.0 mg/L moderate risk; >3.0 mg/L high risk (AHA/CDC for cardiovascular risk).

Related clinical conditions

Related Biomarkers

Frequently measured alongside

GlucoseGluc6 tests InsulinIns2 tests Homeostatic Model Assessment of Insulin ResistanceHOMA-IR2 tests Haemoglobin A1cHbA1c5 tests LipaseLip2 tests Serum Uric AcidUA3 tests

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