What is Noradrenaline?
Noradrenaline is synthesised from dopamine in sympathetic neurones and the adrenal medulla, acting as both a neurotransmitter and a hormone. It drives the sympathetic stress response, elevating heart rate, blood pressure, and alertness. Metabolism proceeds via catechol-O-methyltransferase and monoamine oxidase to normetanephrine and vanillylmandelic acid.