Biomarker Reference · APOE, FTO, TCF7L2, PPARG variants

What does the Cardiometabolic and Lipid Metabolism Single Nucleotide Polymorphisms test measure?

Q: What is the reference range for Cardiometabolic and Lipid Metabolism Single Nucleotide Polymorphisms?

The standard reference range for Cardiometabolic and Lipid Metabolism Single Nucleotide Polymorphisms is Genotype at loci associated with lipid transport, insulin sensitivity, and adiposity.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Cardiometabolic and Lipid Metabolism Single Nucleotide Polymorphisms (APOE, FTO, TCF7L2, PPARG variants) is a clinical biomarker used in genetic-testing assessment. Apolipoprotein E (APOE) isoforms influence lipid clearance and Alzheimer risk; fat mass and obesity-associated protein (FTO) and transcription factor 7-like 2 (TCF7L2) variants modulate adiposity, insulin secretion, and type 2 diabetes susceptibility; peroxisome proliferator-activated receptor gamma (PPARG) regulates adipocyte differentiation and insulin sensitivity. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Genotype at loci associated with lipid transport, insulin sensitivity, and adiposity.
Units: Genotype
Measured In: 1 test
Category: Genetic Testing

Functional medicine optimalNot applicable; results are genotypes. Optimal management is personalised to genotype, phenotype, and modifiable risk factors.

What is Cardiometabolic and Lipid Metabolism Single Nucleotide Polymorphisms?

Apolipoprotein E (APOE) isoforms influence lipid clearance and Alzheimer risk; fat mass and obesity-associated protein (FTO) and transcription factor 7-like 2 (TCF7L2) variants modulate adiposity, insulin secretion, and type 2 diabetes susceptibility; peroxisome proliferator-activated receptor gamma (PPARG) regulates adipocyte differentiation and insulin sensitivity. These variants interact extensively with diet and physical activity.

Why is Cardiometabolic and Lipid Metabolism Single Nucleotide Polymorphisms measured?

Cardiometabolic variants can guide macronutrient distribution (saturated fat responsiveness in APOE4 carriers), inform diabetes and cardiovascular risk stratification, and tailor exercise and dietary interventions. Findings are probabilistic and should be integrated with lipid panels, glucose tolerance, and anthropometric measures rather than used in isolation.

Reference ranges

Standard reference: Genotype at loci associated with lipid transport, insulin sensitivity, and adiposity.
Functional medicine optimal: Not applicable; results are genotypes. Optimal management is personalised to genotype, phenotype, and modifiable risk factors.
Units: Genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Cardiometabolic and Lipid Metabolism Single Nucleotide Polymorphisms

1 test on BiomarkersLabs.com include this biomarker.

BML-GEN-005Comprehensive

3X4 Genetics Test + Blueprint Report

Cardiometabolic and Lipid Metabolism Single Nucleotide Polymorphisms reference range in this test: Genotype at loci associated with lipid transport, insulin sensitivity, and adiposity.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Methylation Pathway Single Nucleotide PolymorphismsMTHFR, MTR, MTRR, COMT variants1 test Phase I and Phase II Detoxification Single Nucleotide PolymorphismsCYP1A2, CYP1B1, GSTT1, GSTM1, NAT2 variants1 test Inflammation and Immune Response Single Nucleotide PolymorphismsIL-6, TNF-α, IL-1β, IL-10 variants1 test Vitamin and Cofactor Metabolism Single Nucleotide PolymorphismsVDR, GC, FUT2, BCMO1 variants1 test Oxidative Stress and Antioxidant Defence Single Nucleotide PolymorphismsSOD2, GPX1, CAT variants1 test

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