Biomarker Reference · VDR, GC, FUT2, BCMO1 variants

What does the Vitamin and Cofactor Metabolism Single Nucleotide Polymorphisms test measure?

Q: What is the reference range for Vitamin and Cofactor Metabolism Single Nucleotide Polymorphisms?

The standard reference range for Vitamin and Cofactor Metabolism Single Nucleotide Polymorphisms is Genotype at loci affecting vitamin D receptor signalling, vitamin D binding, secretor status, and beta-carotene conversion.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Vitamin and Cofactor Metabolism Single Nucleotide Polymorphisms (VDR, GC, FUT2, BCMO1 variants) is a clinical biomarker used in genetic-testing assessment. The vitamin D receptor (VDR) mediates genomic effects of 1,25-dihydroxyvitamin D; vitamin D binding protein (encoded by GC) influences circulating and tissue 25-hydroxyvitamin D; FUT2 secretor status affects gut microbiome composition and B12 absorption; beta-carotene 15,15'-monooxygenase (BCMO1) converts plant carotenoids to retinol. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Genotype at loci affecting vitamin D receptor signalling, vitamin D binding, secretor status, and beta-carotene conversion.
Units: Genotype
Measured In: 1 test
Category: Genetic Testing

Functional medicine optimalNot applicable; results are genotypes. Interpretation is guided by serum 25-hydroxyvitamin D, retinol, and B12 alongside genotype.

What is Vitamin and Cofactor Metabolism Single Nucleotide Polymorphisms?

The vitamin D receptor (VDR) mediates genomic effects of 1,25-dihydroxyvitamin D; vitamin D binding protein (encoded by GC) influences circulating and tissue 25-hydroxyvitamin D; FUT2 secretor status affects gut microbiome composition and B12 absorption; beta-carotene 15,15'-monooxygenase (BCMO1) converts plant carotenoids to retinol. Genetic variation in these pathways alters nutrient bioavailability and requirements.

Why is Vitamin and Cofactor Metabolism Single Nucleotide Polymorphisms measured?

Variants inform targeted supplementation strategies (higher-dose vitamin D for certain VDR or GC genotypes, preformed vitamin A rather than carotenes for poor BCMO1 converters) and may explain discordance between dietary intake and circulating nutrient levels. Direct measurement of nutrient status remains the gold standard for dosing decisions.

Reference ranges

Standard reference: Genotype at loci affecting vitamin D receptor signalling, vitamin D binding, secretor status, and beta-carotene conversion.
Functional medicine optimal: Not applicable; results are genotypes. Interpretation is guided by serum 25-hydroxyvitamin D, retinol, and B12 alongside genotype.
Units: Genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Vitamin and Cofactor Metabolism Single Nucleotide Polymorphisms

1 test on BiomarkersLabs.com include this biomarker.

BML-GEN-005Comprehensive

3X4 Genetics Test + Blueprint Report

Vitamin and Cofactor Metabolism Single Nucleotide Polymorphisms reference range in this test: Genotype at loci affecting vitamin D receptor signalling, vitamin D binding, secretor status, and beta-carotene conversion.

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