Biomarker Reference · CYP1A2, CYP1B1, GSTT1, GSTM1, NAT2 variants

What does the Phase I and Phase II Detoxification Single Nucleotide Polymorphisms test measure?

Q: What is the reference range for Phase I and Phase II Detoxification Single Nucleotide Polymorphisms?

The standard reference range for Phase I and Phase II Detoxification Single Nucleotide Polymorphisms is Presence or absence of functional alleles; rapid, intermediate, or slow metaboliser phenotypes inferred.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Phase I and Phase II Detoxification Single Nucleotide Polymorphisms (CYP1A2, CYP1B1, GSTT1, GSTM1, NAT2 variants) is a clinical biomarker used in genetic-testing assessment. Phase I detoxification is mediated by cytochrome P450 enzymes that add reactive groups to xenobiotics, while phase II conjugation enzymes — including glutathione S-transferases (GST) and N-acetyltransferases (NAT) — render intermediates water-soluble for excretion. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Presence or absence of functional alleles; rapid, intermediate, or slow metaboliser phenotypes inferred.
Units: Genotype
Measured In: 1 test
Category: Genetic Testing

Functional medicine optimalNot applicable; results are genotypes. Clinical relevance depends on exposure history, biochemical measures of oxidative stress, and concurrent conditions.

What is Phase I and Phase II Detoxification Single Nucleotide Polymorphisms?

Phase I detoxification is mediated by cytochrome P450 enzymes that add reactive groups to xenobiotics, while phase II conjugation enzymes — including glutathione S-transferases (GST) and N-acetyltransferases (NAT) — render intermediates water-soluble for excretion. Genetic polymorphisms can create rapid or slow metaboliser phenotypes, altering the clearance of environmental toxins, pharmaceuticals, and endogenous compounds such as oestrogens.

Why is Phase I and Phase II Detoxification Single Nucleotide Polymorphisms measured?

Detoxification variants influence individual responses to environmental exposures, caffeine metabolism, breast cancer risk modulation (particularly CYP1B1 in oestrogen metabolism), and may guide personalised recommendations around cruciferous vegetable intake, antioxidant support, and exposure minimisation. Functional interpretation remains exploratory and is not a substitute for standard toxicology or pharmacogenomic testing.

Reference ranges

Standard reference: Presence or absence of functional alleles; rapid, intermediate, or slow metaboliser phenotypes inferred.
Functional medicine optimal: Not applicable; results are genotypes. Clinical relevance depends on exposure history, biochemical measures of oxidative stress, and concurrent conditions.
Units: Genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Phase I and Phase II Detoxification Single Nucleotide Polymorphisms

1 test on BiomarkersLabs.com include this biomarker.

BML-GEN-005Comprehensive

3X4 Genetics Test + Blueprint Report

Phase I and Phase II Detoxification Single Nucleotide Polymorphisms reference range in this test: Presence or absence of functional alleles; rapid, intermediate, or slow metaboliser phenotypes inferred.

Related clinical conditions

Related Biomarkers

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