Biomarker Reference · SOD2, GPX1, CAT variants

What does the Oxidative Stress and Antioxidant Defence Single Nucleotide Polymorphisms test measure?

Q: What is the reference range for Oxidative Stress and Antioxidant Defence Single Nucleotide Polymorphisms?

The standard reference range for Oxidative Stress and Antioxidant Defence Single Nucleotide Polymorphisms is Genotype at superoxide dismutase, glutathione peroxidase, and catalase loci.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Oxidative Stress and Antioxidant Defence Single Nucleotide Polymorphisms (SOD2, GPX1, CAT variants) is a clinical biomarker used in genetic-testing assessment. Superoxide dismutase 2 (SOD2) converts mitochondrial superoxide to hydrogen peroxide, glutathione peroxidase (GPX1) reduces peroxides using glutathione, and catalase (CAT) degrades hydrogen peroxide to water. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Genotype at superoxide dismutase, glutathione peroxidase, and catalase loci.
Units: Genotype
Measured In: 1 test
Category: Genetic Testing

Functional medicine optimalNot applicable; results are genotypes. Management is tailored to oxidative load and antioxidant capacity.

What is Oxidative Stress and Antioxidant Defence Single Nucleotide Polymorphisms?

Superoxide dismutase 2 (SOD2) converts mitochondrial superoxide to hydrogen peroxide, glutathione peroxidase (GPX1) reduces peroxides using glutathione, and catalase (CAT) degrades hydrogen peroxide to water. Polymorphisms can reduce enzyme efficiency, increasing susceptibility to oxidative damage under conditions of metabolic or environmental stress.

Why is Oxidative Stress and Antioxidant Defence Single Nucleotide Polymorphisms measured?

Variants in antioxidant enzymes may guide the use of dietary antioxidants, support for glutathione synthesis (N-acetylcysteine, glycine, selenium), and mitigation of oxidative triggers (smoking, pollution, high-intensity exercise). These are functional insights, not diagnostic markers, and should be integrated with oxidative stress biomarkers such as 8-hydroxy-2'-deoxyguanosine or lipid peroxides where available.

Reference ranges

Standard reference: Genotype at superoxide dismutase, glutathione peroxidase, and catalase loci.
Functional medicine optimal: Not applicable; results are genotypes. Management is tailored to oxidative load and antioxidant capacity.
Units: Genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Oxidative Stress and Antioxidant Defence Single Nucleotide Polymorphisms

1 test on BiomarkersLabs.com include this biomarker.

BML-GEN-005Comprehensive

3X4 Genetics Test + Blueprint Report

Oxidative Stress and Antioxidant Defence Single Nucleotide Polymorphisms reference range in this test: Genotype at superoxide dismutase, glutathione peroxidase, and catalase loci.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Methylation Pathway Single Nucleotide PolymorphismsMTHFR, MTR, MTRR, COMT variants1 test Phase I and Phase II Detoxification Single Nucleotide PolymorphismsCYP1A2, CYP1B1, GSTT1, GSTM1, NAT2 variants1 test Inflammation and Immune Response Single Nucleotide PolymorphismsIL-6, TNF-α, IL-1β, IL-10 variants1 test Cardiometabolic and Lipid Metabolism Single Nucleotide PolymorphismsAPOE, FTO, TCF7L2, PPARG variants1 test Vitamin and Cofactor Metabolism Single Nucleotide PolymorphismsVDR, GC, FUT2, BCMO1 variants1 test

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