Which tests measure Melatonin (6-Hydroxymelatonin Sulphate)?

Melatonin (6-Hydroxymelatonin Sulphate) is measured in 1 test on BiomarkersLabs.com, including DUTCH Plus (Dried Urine Test for Comprehensive Hormones, Plus Salivary Cortisol Awakening Response).

Biomarker Reference · 6-OHMS

What does the Melatonin (6-Hydroxymelatonin Sulphate) test measure?

Q: What is the reference range for Melatonin (6-Hydroxymelatonin Sulphate)?

The standard reference range for Melatonin (6-Hydroxymelatonin Sulphate) is Method-specific dried-urine intervals, interpreted against the overnight/waking collection # REVIEWER FLAG: Urinary 6-OHMS intervals are method-specific — reviewer to confirm against the laboratory's protocol.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Melatonin (6-Hydroxymelatonin Sulphate) (6-OHMS) is a clinical biomarker used in adrenal-stress assessment. Melatonin, secreted by the pineal gland with a nocturnal peak, is metabolised principally to 6-hydroxymelatonin sulphate, which is excreted in urine and serves as a validated surrogate of melatonin production. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Method-specific dried-urine intervals, interpreted against the overnight/waking collection # REVIEWER FLAG: Urinary 6-OHMS intervals are method-specific — reviewer to confirm against the laboratory's protocol.
Units: ng/mg creatinine
Measured In: 1 test
Category: Adrenal

Functional medicine optimalInterpreted against expected overnight production rather than a fixed target

What is Melatonin (6-Hydroxymelatonin Sulphate)?

Melatonin, secreted by the pineal gland with a nocturnal peak, is metabolised principally to 6-hydroxymelatonin sulphate, which is excreted in urine and serves as a validated surrogate of melatonin production. The dried-urine waking sample captures overnight melatonin output. It reflects circadian melatonin secretion rather than an instantaneous level.

Why is Melatonin (6-Hydroxymelatonin Sulphate) measured?

Urinary 6-OHMS is used to estimate overnight melatonin production in the assessment of circadian rhythm and sleep complaints within functional practice. It complements the cortisol rhythm in characterising circadian function and is interpreted as a surrogate of melatonin output.

Reference ranges

Standard reference: Method-specific dried-urine intervals, interpreted against the overnight/waking collection # REVIEWER FLAG: Urinary 6-OHMS intervals are method-specific — reviewer to confirm against the laboratory's protocol.
Functional medicine optimal: Interpreted against expected overnight production rather than a fixed target
Units: ng/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Melatonin (6-Hydroxymelatonin Sulphate)

1 test on BiomarkersLabs.com include this biomarker.

BML-ADR-013Comprehensive

DUTCH Plus (Dried Urine Test for Comprehensive Hormones, Plus Salivary Cortisol Awakening Response)

Melatonin (6-Hydroxymelatonin Sulphate) reference range in this test: Method-specific dried-urine intervals, interpreted against the overnight/waking collection # REVIEWER FLAG: Urinary 6-OHMS intervals are method-specific — reviewer to confirm against the laboratory's protocol.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Free Cortisol Diurnal Pattern (Dried Urine)Free Cortisol1 test Cortisol Awakening ResponseCAR6 tests Cortisol Metabolites (a-Tetrahydrocortisol, b-Tetrahydrocortisol, Tetrahydrocortisone)Metabolised Cortisol1 test DHEA-S and Androgen Metabolites (Testosterone, 5a-DHT metabolites, Etiocholanolone, Androsterone)Androgens1 test Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways)Oestrogens2 tests Progesterone Metabolites (a-Pregnanediol, b-Pregnanediol)Progesterone Metabolites2 tests Oxidative Stress and Organic Acid Markers (8-OHdG and selected OATs)8-OHdG / OATs1 test

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