What is Progesterone Metabolites (a-Pregnanediol, b-Pregnanediol)?
Progesterone is metabolised to pregnanediol isomers excreted in urine, which serve as a surrogate for progesterone production over the collection window. Because progesterone itself is not measured directly in dried urine, these metabolites are used to estimate luteal-phase progesterone activity. Levels vary markedly with cycle phase and are minimal outside the luteal phase and in postmenopausal women.