Biomarker Reference · Oestrogens

What does the Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways) test measure?

Q: What is the reference range for Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways)?

The standard reference range for Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways) is Sex-, cycle-, and menopausal-status-specific dried-urine intervals reported per metabolite # REVIEWER FLAG: Oestrogen-metabolite reference intervals are sex-, cycle-, and menopausal-status-specific and proprietary to the Precision Analytical dried-urine method; not interchangeable with serum — reviewer to confirm against the laboratory's current intervals.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways) (Oestrogens) is a clinical biomarker used in adrenal-stress assessment. Oestrogens (oestrone, oestradiol, oestriol) are metabolised through three hydroxylation pathways — 2-hydroxy, 4-hydroxy, and 16-hydroxy — followed by methylation. It is measured in 2 laboratory tests on BiomarkersLabs.com.

Reference Range: Sex-, cycle-, and menopausal-status-specific dried-urine intervals reported per metabolite # REVIEWER FLAG: Oestrogen-metabolite reference intervals are sex-, cycle-, and menopausal-status-specific and proprietary to the Precision Analytical dried-urine method; not interchangeable with serum — reviewer to confirm against the laboratory's current intervals.
Units: ng/mg creatinine, pg/mg creatinine
Measured In: 2 tests
Category: Adrenal

Functional medicine optimalPathway-balance interpretation rather than a single optimal value

What is Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways)?

Oestrogens (oestrone, oestradiol, oestriol) are metabolised through three hydroxylation pathways — 2-hydroxy, 4-hydroxy, and 16-hydroxy — followed by methylation. The relative flux through these pathways and the degree of methylation are of interest because the 4-OH pathway generates more reactive metabolites. Dried urine measures the parent oestrogens together with these downstream metabolites over the collection window.

Why is Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways) measured?

Oestrogen-metabolite profiling is used in functional and integrative practice to examine oestrogen production and the balance of metabolic pathways, including methylation capacity. Interpretation regarding pathway 'preference' and any associated risk is an area of active research and is not an established clinical risk-stratification tool. Results are interpreted with cycle timing, menopausal status, and any hormone therapy.

Reference ranges

Standard reference: Sex-, cycle-, and menopausal-status-specific dried-urine intervals reported per metabolite # REVIEWER FLAG: Oestrogen-metabolite reference intervals are sex-, cycle-, and menopausal-status-specific and proprietary to the Precision Analytical dried-urine method; not interchangeable with serum — reviewer to confirm against the laboratory's current intervals.
Functional medicine optimal: Pathway-balance interpretation rather than a single optimal value
Units: ng/mg creatinine, pg/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways)

2 tests on BiomarkersLabs.com include this biomarker.

BML-ADR-013Comprehensive

DUTCH Plus (Dried Urine Test for Comprehensive Hormones, Plus Salivary Cortisol Awakening Response)

Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways) reference range in this test: Sex-, cycle-, and method-specific dried-urine intervals # REVIEWER FLAG: Oestrogen-metabolite reference intervals are sex-, cycle-, and menopausal-status-specific and proprietary — reviewer to confirm against the laboratory's current intervals.

BML-HRF-005Comprehensive

DUTCH Sex Hormone Metabolites (Dried Urine)

Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways) reference range in this test: Sex-, cycle-, and menopausal-status-specific dried-urine intervals reported per metabolite # REVIEWER FLAG: Oestrogen-metabolite reference intervals are sex-, cycle-, and menopausal-status-specific and proprietary to the Precision Analytical dried-urine method; not interchangeable with serum — reviewer to confirm against the laboratory's current intervals.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Progesterone Metabolites (a-Pregnanediol, b-Pregnanediol)Progesterone Metabolites2 tests Free Cortisol Diurnal Pattern (Dried Urine)Free Cortisol1 test Cortisol Awakening ResponseCAR6 tests Cortisol Metabolites (a-Tetrahydrocortisol, b-Tetrahydrocortisol, Tetrahydrocortisone)Metabolised Cortisol1 test DHEA-S and Androgen Metabolites (Testosterone, 5a-DHT metabolites, Etiocholanolone, Androsterone)Androgens1 test Melatonin (6-Hydroxymelatonin Sulphate)6-OHMS1 test Oxidative Stress and Organic Acid Markers (8-OHdG and selected OATs)8-OHdG / OATs1 test Androgen Metabolites (DHEA-S, Testosterone, 5a-DHT metabolites, Androsterone, Etiocholanolone)Androgens1 test

Order tests measuring Oestrogen Metabolites (Oestrone, Oestradiol, Oestriol and 2-OH, 4-OH, 16-OH pathways) for your patients

Available exclusively to verified licensed healthcare practitioners. CLIA-certified laboratory results delivered to your secure portal.

Create Free Account