What is the reference range for 16α-Hydroxyestrone?

The standard reference range for 16α-Hydroxyestrone is Method-specific; premenopausal 2–15, postmenopausal 1–8 ng/mg creatinine (approximate).. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure 16α-Hydroxyestrone?

16α-Hydroxyestrone is measured in 1 test on BiomarkersLabs.com, including Dried Urine GCMS Estrogen Hormone Metabolites.

Biomarker Reference · 16α-OH-E1

What does the 16α-Hydroxyestrone test measure?

16α-Hydroxyestrone (16α-OH-E1) is a clinical biomarker used in female-hormones assessment. 16α-Hydroxyestrone is produced by cytochrome P450 3A4 and other enzymes via hydroxylation at the C16α position. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Method-specific; premenopausal 2–15, postmenopausal 1–8 ng/mg creatinine (approximate).
Units: ng/mg creatinine
Measured In: 1 test
Category: Female Hormones

Functional medicine optimalFunctional models favour lower 16α-OH-E1 relative to 2-OH pathways; specific thresholds are laboratory- and population-dependent.

What is 16α-Hydroxyestrone?

16α-Hydroxyestrone is produced by cytochrome P450 3A4 and other enzymes via hydroxylation at the C16α position. It retains significant oestrogenic potency, binds covalently to the oestrogen receptor, and stimulates cellular proliferation more persistently than parent oestrogens.

Why is 16α-Hydroxyestrone measured?

Higher 16α-OH-E1 has been associated in some case-control and mechanistic studies with increased breast cancer risk, though findings are inconsistent. The 2:16α ratio is used in functional medicine as a metabolic risk index; lower ratios prompt dietary and supplemental interventions.

Reference ranges

Standard reference: Method-specific; premenopausal 2–15, postmenopausal 1–8 ng/mg creatinine (approximate).
Functional medicine optimal: Functional models favour lower 16α-OH-E1 relative to 2-OH pathways; specific thresholds are laboratory- and population-dependent.
Units: ng/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure 16α-Hydroxyestrone

1 test on BiomarkersLabs.com include this biomarker.

BML-HRF-024Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites

16α-Hydroxyestrone reference range in this test: Method-specific; premenopausal 2–15, postmenopausal 1–8 ng/mg creatinine (approximate).

Related clinical conditions

Related Biomarkers

Frequently measured alongside

EstroneE15 tests EstradiolE25 tests EstriolE35 tests 2-Hydroxyestrone2-OH-E11 test 4-Hydroxyestrone4-OH-E11 test 2-Hydroxyestrone : 16α-Hydroxyestrone Ratio2:16α-OH-E11 test 2-Methoxyestrone2-MeOE11 test 4-Methoxyestrone4-MeOE11 test

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