Biomarker Reference · 2:16α-OH-E1
2-Hydroxyestrone : 16α-Hydroxyestrone Ratio (2:16α-OH-E1) is a clinical biomarker used in female-hormones assessment. The 2:16α ratio quantifies the balance between the putatively protective 2-hydroxylation pathway and the more proliferative 16α pathway. It is measured in 1 laboratory test on BiomarkersLabs.com.
The 2:16α ratio quantifies the balance between the putatively protective 2-hydroxylation pathway and the more proliferative 16α pathway. It reflects the composite activity of competing cytochrome P450 isoforms, influenced by genetics, diet (cruciferous vegetables, fibre), obesity, and xenobiotic exposure.
A higher 2:16α ratio has been associated with lower breast cancer risk in early case-control studies, though larger prospective cohorts have yielded mixed results. Functional practitioners use it to guide dietary and supplement interventions (indole-3-carbinol, DIM, flaxseed), but its predictive value for individual cancer risk remains contested.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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