What is the reference range for 2-Hydroxyestrone?

The standard reference range for 2-Hydroxyestrone is Method-specific; premenopausal 2–20, postmenopausal 1–10 ng/mg creatinine (approximate).. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure 2-Hydroxyestrone?

2-Hydroxyestrone is measured in 1 test on BiomarkersLabs.com, including Dried Urine GCMS Estrogen Hormone Metabolites.

Biomarker Reference · 2-OH-E1

What does the 2-Hydroxyestrone test measure?

2-Hydroxyestrone (2-OH-E1) is a clinical biomarker used in female-hormones assessment. 2-Hydroxyestrone is formed by cytochrome P450 1A1 and 1A2 hydroxylation of oestrone at the C2 position. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Method-specific; premenopausal 2–20, postmenopausal 1–10 ng/mg creatinine (approximate).
Units: ng/mg creatinine
Measured In: 1 test
Category: Female Hormones

Functional medicine optimalFunctional thresholds favour 2-OH-E1 predominance; specific cut-offs are assay-dependent and should be interpreted in the context of total oestrogen load and clinical risk.

What is 2-Hydroxyestrone?

2-Hydroxyestrone is formed by cytochrome P450 1A1 and 1A2 hydroxylation of oestrone at the C2 position. It has weak oestrogenic activity and is catabolised rapidly via catechol-O-methyltransferase to methoxyoestradiols, which are excreted. This pathway is considered the predominant 'protective' route of oestrogen metabolism.

Why is 2-Hydroxyestrone measured?

Higher 2-OH-E1 is associated in epidemiological and mechanistic studies with lower breast and endometrial cancer risk. Practitioners use the 2-OH to 16α-OH ratio as a marker of metabolic balance; a higher ratio is interpreted as favourable.

Reference ranges

Standard reference: Method-specific; premenopausal 2–20, postmenopausal 1–10 ng/mg creatinine (approximate).
Functional medicine optimal: Functional thresholds favour 2-OH-E1 predominance; specific cut-offs are assay-dependent and should be interpreted in the context of total oestrogen load and clinical risk.
Units: ng/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure 2-Hydroxyestrone

1 test on BiomarkersLabs.com include this biomarker.

BML-HRF-024Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites

2-Hydroxyestrone reference range in this test: Method-specific; premenopausal 2–20, postmenopausal 1–10 ng/mg creatinine (approximate).

Related clinical conditions

Related Biomarkers

Frequently measured alongside

EstroneE15 tests EstradiolE25 tests EstriolE35 tests 4-Hydroxyestrone4-OH-E11 test 16α-Hydroxyestrone16α-OH-E11 test 2-Hydroxyestrone : 16α-Hydroxyestrone Ratio2:16α-OH-E11 test 2-Methoxyestrone2-MeOE11 test 4-Methoxyestrone4-MeOE11 test

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