Which tests measure Estriol?

Estriol is measured in 5 tests on BiomarkersLabs.com, including Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I, Dried Urine GCMS Estrogen Hormone Metabolites, Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I.

Biomarker Reference · E3

What does the Estriol test measure?

Q: What is the reference range for Estriol?

The standard reference range for Estriol is Non-pregnant premenopausal 2–10 ng/mg Cr; postmenopausal 1–5 ng/mg Cr. Rises dramatically in pregnancy. Method- and laboratory-specific.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Estriol (E3) is a clinical biomarker used in female-hormones assessment. Estriol is a weak oestrogen produced in small amounts by ovarian and adrenal pathways, with large placental synthesis during pregnancy. It is measured in 5 laboratory tests on BiomarkersLabs.com.

Reference Range: Non-pregnant premenopausal 2–10 ng/mg Cr; postmenopausal 1–5 ng/mg Cr. Rises dramatically in pregnancy. Method- and laboratory-specific.
Units: pg/mg creatinine, ng/mg creatinine, ng/24hr, µg/24hr
Measured In: 5 tests
Category: Female Hormones

Functional medicine optimalNo single optimal range is established for non-pregnant women; interpretation focuses on the ratio of estriol to other metabolites and the overall metabolic profile rather than the absolute level.

What is Estriol?

Estriol is a weak oestrogen produced in small amounts by ovarian and adrenal pathways, with large placental synthesis during pregnancy. Outside pregnancy, oestriol represents a terminal metabolite of oestrone and oestradiol, and its measurement in 24-hour urine reflects the overall flux through oestrogenic pathways. It has the lowest receptor affinity of the three classical oestrogens.

Why is Estriol measured?

Non-pregnant oestriol is primarily of interest in functional and integrative medicine, where it is thought to reflect metabolic clearance of more potent oestrogens. Some practitioners use oestriol in topical or oral bioidentical formulations, citing a favourable safety profile for vaginal and urogenital symptoms, though its routine measurement in non-pregnant women lacks strong evidence-based clinical indications.

Reference ranges

Standard reference: Non-pregnant premenopausal 2–10 ng/mg Cr; postmenopausal 1–5 ng/mg Cr. Rises dramatically in pregnancy. Method- and laboratory-specific.
Functional medicine optimal: No single optimal range is established for non-pregnant women; interpretation focuses on the ratio of estriol to other metabolites and the overall metabolic profile rather than the absolute level.
Units: pg/mg creatinine, ng/mg creatinine, ng/24hr, µg/24hr

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Estriol

5 tests on BiomarkersLabs.com include this biomarker.

BML-THY-031Comprehensive

Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

Estriol reference range in this test: Dried urine: varies by sex, menopausal status, and pregnancy status; proprietary method-specific intervals.

BML-HRF-024Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites

Estriol reference range in this test: Method-specific; non-pregnant 1–10, pregnant ranges rise progressively; postmenopausal <2 ng/mg creatinine (approximate).

BML-HRF-023Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

Estriol reference range in this test: Non-pregnant <1 ng/mg creatinine; pregnancy values rise markedly.

BML-HRF-025Comprehensive

Essential Estrogens™ - 24 hr

Estriol reference range in this test: Premenopausal <10 ng/24hr; postmenopausal <5 ng/24hr; markedly elevated in pregnancy; method- and laboratory-specific.

BML-HRF-026Comprehensive

Essential Estrogens™ - FMV

Estriol reference range in this test: Non-pregnant premenopausal 2–10 ng/mg Cr; postmenopausal 1–5 ng/mg Cr. Rises dramatically in pregnancy. Method- and laboratory-specific.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

EstroneE15 tests EstradiolE25 tests 2-Hydroxyestrone2-OHE14 tests 4-Hydroxyestrone4-OHE14 tests 16α-Hydroxyestrone16α-OHE13 tests 2-Methoxyestrone2-MeOE14 tests 4-Methoxyestrone4-MeOE13 tests 2-Hydroxyestradiol2-OHE22 tests

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