What is the reference range for 2-Methoxyestrone?

The standard reference range for 2-Methoxyestrone is Premenopausal 2–10 ng/mg Cr; postmenopausal 1–5 ng/mg Cr. Method- and laboratory-specific.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure 2-Methoxyestrone?

2-Methoxyestrone is measured in 4 tests on BiomarkersLabs.com, including Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites, Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I, Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I.

Biomarker Reference · 2-MeOE1

What does the 2-Methoxyestrone test measure?

2-Methoxyestrone (2-MeOE1) is a clinical biomarker used in thyroid-endocrine assessment. 2-Methoxyestrone is formed by COMT-mediated O-methylation of 2-hydroxyestrone. It is measured in 4 laboratory tests on BiomarkersLabs.com.

Reference Range: Premenopausal 2–10 ng/mg Cr; postmenopausal 1–5 ng/mg Cr. Method- and laboratory-specific.
Units: pg/mg creatinine, ng/mg creatinine
Measured In: 4 tests
Category: Thyroid

Functional medicine optimalHigher 2-MeOE1 relative to unmethylated 2-OHE1 is interpreted as robust methylation and favourable detoxification.

What is 2-Methoxyestrone?

2-Methoxyestrone is formed by COMT-mediated O-methylation of 2-hydroxyestrone. Methylation inactivates the catechol, preventing redox cycling and facilitating excretion. Adequate methylation capacity, supported by folate and other methyl donors, is considered protective.

Why is 2-Methoxyestrone measured?

This metabolite reflects the efficiency of catechol methylation. Low 2-methoxyestrone relative to 2-hydroxyestrone may suggest limited COMT activity or methyl-donor deficiency, prompting assessment of folate, B12, and genetic polymorphisms in COMT, though clinical interventions targeting methylation are still investigational.

Reference ranges

Standard reference: Premenopausal 2–10 ng/mg Cr; postmenopausal 1–5 ng/mg Cr. Method- and laboratory-specific.
Functional medicine optimal: Higher 2-MeOE1 relative to unmethylated 2-OHE1 is interpreted as robust methylation and favourable detoxification.
Units: pg/mg creatinine, ng/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure 2-Methoxyestrone

4 tests on BiomarkersLabs.com include this biomarker.

BML-THY-032Comprehensive

Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites

2-Methoxyestrone reference range in this test: Laboratory-provided; reflects phase II methylation capacity.

BML-THY-031Comprehensive

Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

2-Methoxyestrone reference range in this test: Dried urine: proprietary method-specific intervals; no consensus clinical reference.

BML-HRF-023Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

2-Methoxyestrone reference range in this test: Typically 0.2–2 ng/mg creatinine.

BML-HRF-026Comprehensive

Essential Estrogens™ - FMV

2-Methoxyestrone reference range in this test: Premenopausal 2–10 ng/mg Cr; postmenopausal 1–5 ng/mg Cr. Method- and laboratory-specific.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

EstroneE15 tests EstradiolE25 tests EstriolE35 tests 2-Hydroxyestrone2-OHE14 tests 4-Hydroxyestrone4-OHE14 tests 16α-Hydroxyestrone16α-OHE13 tests 4-Methoxyestrone4-MeOE13 tests 2-Hydroxyestradiol2-OHE22 tests

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