Which tests measure Estrone?

Estrone is measured in 5 tests on BiomarkersLabs.com, including Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I, Dried Urine GCMS Estrogen Hormone Metabolites, Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I.

Biomarker Reference · E1

What does the Estrone test measure?

Q: What is the reference range for Estrone?

The standard reference range for Estrone is Premenopausal follicular 5–15 ng/mg Cr; luteal 10–40 ng/mg Cr; postmenopausal 2–8 ng/mg Cr. Method- and laboratory-specific.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Estrone (E1) is a clinical biomarker used in female-hormones assessment. Estrone is synthesised in the ovaries and by peripheral aromatisation of androstenedione in adipose tissue, with the latter route dominating after menopause. It is measured in 5 laboratory tests on BiomarkersLabs.com.

Reference Range: Premenopausal follicular 5–15 ng/mg Cr; luteal 10–40 ng/mg Cr; postmenopausal 2–8 ng/mg Cr. Method- and laboratory-specific.
Units: pg/mg creatinine, ng/mg creatinine, ng/24hr, µg/24hr
Measured In: 5 tests
Category: Female Hormones

Functional medicine optimalOptimal ranges are context-dependent: reproductive-aged women require adequate estrone for ovulation and endometrial development, while minimising excess exposure; postmenopausal women benefit from low-normal values that maintain bone and vascular health without excessive proliferative signalling.

What is Estrone?

Estrone is synthesised in the ovaries and by peripheral aromatisation of androstenedione in adipose tissue, with the latter route dominating after menopause. It can be interconverted with estradiol by 17β-hydroxysteroid dehydrogenase and undergoes irreversible hydroxylation along multiple pathways. In urine, estrone and its phase-I and phase-II metabolites reflect integrated production and metabolism over the collection interval.

Why is Estrone measured?

Elevated oestrone in postmenopausal women may reflect increased adipose aromatase activity or exogenous hormone exposure, a pattern associated with endometrial and breast cancer risk. Low oestrone in premenopausal women can signal ovarian insufficiency or hypothalamic amenorrhoea. The 24-hour integrated measurement reduces fluctuation seen with single serum samples.

Reference ranges

Standard reference: Premenopausal follicular 5–15 ng/mg Cr; luteal 10–40 ng/mg Cr; postmenopausal 2–8 ng/mg Cr. Method- and laboratory-specific.
Functional medicine optimal: Optimal ranges are context-dependent: reproductive-aged women require adequate estrone for ovulation and endometrial development, while minimising excess exposure; postmenopausal women benefit from low-normal values that maintain bone and vascular health without excessive proliferative signalling.
Units: pg/mg creatinine, ng/mg creatinine, ng/24hr, µg/24hr

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Estrone

5 tests on BiomarkersLabs.com include this biomarker.

BML-THY-031Comprehensive

Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

Estrone reference range in this test: Dried urine: varies by sex, menopausal status, and phase; proprietary method-specific intervals.

BML-HRF-024Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites

Estrone reference range in this test: Method-specific; follicular 5–25, luteal 10–40, postmenopausal 2–15 ng/mg creatinine (approximate).

BML-HRF-023Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

Estrone reference range in this test: Luteal phase 2–10 ng/mg creatinine; ranges vary by menopausal status and collection timing.

BML-HRF-025Comprehensive

Essential Estrogens™ - 24 hr

Estrone reference range in this test: Premenopausal follicular 2–25 ng/24hr, luteal 4–35 ng/24hr; postmenopausal <10 ng/24hr; method- and laboratory-specific.

BML-HRF-026Comprehensive

Essential Estrogens™ - FMV

Estrone reference range in this test: Premenopausal follicular 5–15 ng/mg Cr; luteal 10–40 ng/mg Cr; postmenopausal 2–8 ng/mg Cr. Method- and laboratory-specific.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

EstradiolE25 tests EstriolE35 tests 2-Hydroxyestrone2-OHE14 tests 4-Hydroxyestrone4-OHE14 tests 16α-Hydroxyestrone16α-OHE13 tests 2-Methoxyestrone2-MeOE14 tests 4-Methoxyestrone4-MeOE13 tests 2-Hydroxyestradiol2-OHE22 tests

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