What is 4-Methoxyestrone?
4-Methoxyestrone is the methylated conjugate of 4-hydroxyestrone, produced by COMT. Methylation prevents quinone formation and is considered protective against oxidative DNA damage in functional models.
Biomarker Reference · 4-MeOE1
4-Methoxyestrone (4-MeOE1) is a clinical biomarker used in thyroid-endocrine assessment. 4-Methoxyestrone is the methylated conjugate of 4-hydroxyestrone, produced by COMT. It is measured in 3 laboratory tests on BiomarkersLabs.com.
4-Methoxyestrone is the methylated conjugate of 4-hydroxyestrone, produced by COMT. Methylation prevents quinone formation and is considered protective against oxidative DNA damage in functional models.
The 4-MeOE1 level and its ratio to unmethylated 4-OHE1 reflect the efficiency of phase II detoxification of the genotoxic 4-pathway. Low methylation in the presence of elevated 4-hydroxy metabolites is flagged as a potential risk marker.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
3 tests on BiomarkersLabs.com include this biomarker.
4-Methoxyestrone reference range in this test: Typically lower than 2-methoxy metabolites; laboratory interval applies.
4-Methoxyestrone reference range in this test: Dried urine: proprietary method-specific intervals; no consensus clinical reference.
4-Methoxyestrone reference range in this test: Typically <0.5 ng/mg creatinine.
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