Which tests measure Estradiol?

Estradiol is measured in 5 tests on BiomarkersLabs.com, including Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I, Dried Urine GCMS Estrogen Hormone Metabolites, Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I.

Biomarker Reference · E2

What does the Estradiol test measure?

Q: What is the reference range for Estradiol?

The standard reference range for Estradiol is Premenopausal follicular 2–8 ng/mg Cr; luteal 5–20 ng/mg Cr; postmenopausal 0.5–3 ng/mg Cr. Method- and laboratory-specific.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Estradiol (E2) is a clinical biomarker used in female-hormones assessment. Estradiol is the most potent circulating oestrogen, produced primarily by the ovarian granulosa cells in premenopausal women and by peripheral conversion in adipose and other tissues after menopause. It is measured in 5 laboratory tests on BiomarkersLabs.com.

Reference Range: Premenopausal follicular 2–8 ng/mg Cr; luteal 5–20 ng/mg Cr; postmenopausal 0.5–3 ng/mg Cr. Method- and laboratory-specific.
Units: pg/mg creatinine, ng/mg creatinine, ng/24hr, µg/24hr
Measured In: 5 tests
Category: Female Hormones

Functional medicine optimalReproductive-aged women require mid-follicular levels sufficient to support endometrial development and mid-luteal levels that sustain early pregnancy; postmenopausal women benefit from lower levels that preserve skeletal and cardiovascular health while avoiding proliferative risk.

What is Estradiol?

Estradiol is the most potent circulating oestrogen, produced primarily by the ovarian granulosa cells in premenopausal women and by peripheral conversion in adipose and other tissues after menopause. It binds oestrogen receptors with high affinity, drives endometrial proliferation, maintains bone density, and regulates lipid metabolism. Urinary excretion reflects both free and conjugated forms, integrated over the collection period.

Why is Estradiol measured?

Oestradiol is central to reproductive function, bone health, cardiovascular protection, and cognitive well-being. A 24-hour urine collection smooths diurnal and pulsatile variation, making it useful for assessing overall oestrogenic status in perimenopause, monitoring oestrogen replacement, and evaluating suspected hypoestrogenism in women with amenorrhoea or premature ovarian insufficiency.

Reference ranges

Standard reference: Premenopausal follicular 2–8 ng/mg Cr; luteal 5–20 ng/mg Cr; postmenopausal 0.5–3 ng/mg Cr. Method- and laboratory-specific.
Functional medicine optimal: Reproductive-aged women require mid-follicular levels sufficient to support endometrial development and mid-luteal levels that sustain early pregnancy; postmenopausal women benefit from lower levels that preserve skeletal and cardiovascular health while avoiding proliferative risk.
Units: pg/mg creatinine, ng/mg creatinine, ng/24hr, µg/24hr

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Estradiol

5 tests on BiomarkersLabs.com include this biomarker.

BML-THY-031Comprehensive

Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

Estradiol reference range in this test: Dried urine: varies by sex, menopausal status, and phase; proprietary method-specific intervals.

BML-HRF-024Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites

Estradiol reference range in this test: Method-specific; follicular 1–10, ovulatory 5–30, luteal 2–15, postmenopausal 0.5–3 ng/mg creatinine (approximate).

BML-HRF-023Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

Estradiol reference range in this test: Follicular phase 1–5 ng/mg creatinine, luteal phase 2–8 ng/mg creatinine; postmenopausal <2 ng/mg creatinine.

BML-HRF-025Comprehensive

Essential Estrogens™ - 24 hr

Estradiol reference range in this test: Premenopausal follicular 3–20 ng/24hr, luteal 5–30 ng/24hr; postmenopausal <5 ng/24hr; method- and laboratory-specific.

BML-HRF-026Comprehensive

Essential Estrogens™ - FMV

Estradiol reference range in this test: Premenopausal follicular 2–8 ng/mg Cr; luteal 5–20 ng/mg Cr; postmenopausal 0.5–3 ng/mg Cr. Method- and laboratory-specific.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

EstroneE15 tests EstriolE35 tests 2-Hydroxyestrone2-OHE14 tests 4-Hydroxyestrone4-OHE14 tests 16α-Hydroxyestrone16α-OHE13 tests 2-Methoxyestrone2-MeOE14 tests 4-Methoxyestrone4-MeOE13 tests 2-Hydroxyestradiol2-OHE22 tests

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