Biomarker Reference · 2-OHE1
2-Hydroxyestrone (2-OHE1) is a clinical biomarker used in female-hormones assessment. 2-Hydroxyestrone is a principal catechol oestrogen metabolite formed by cytochrome P450 1A1/1A2 hydroxylation of oestrone and oestradiol. It is measured in 4 laboratory tests on BiomarkersLabs.com.
2-Hydroxyestrone is a principal catechol oestrogen metabolite formed by cytochrome P450 1A1/1A2 hydroxylation of oestrone and oestradiol. It is considered a 'favourable' or 'protective' metabolite with weak oestrogenic activity, minimal proliferative effect, and possible antiproliferative actions. It is rapidly methylated by catechol-O-methyltransferase to methoxy derivatives or conjugated for excretion.
Higher 2-hydroxylation relative to other pathways has been associated in some observational studies with lower breast and endometrial cancer risk, though causality is unproven. Practitioners use the absolute level and ratio of 2-hydroxyestrone to the 16α and 4-hydroxy pathways as a metabolic 'profile', informing nutritional and supplement interventions aimed at favouring the 2-pathway.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
4 tests on BiomarkersLabs.com include this biomarker.
2-Hydroxyestrone reference range in this test: Dried urine: proprietary method-specific intervals; no consensus clinical reference.
2-Hydroxyestrone reference range in this test: Typically 1–8 ng/mg creatinine; varies by hormonal status.
2-Hydroxyestrone reference range in this test: Premenopausal 2–15 ng/24hr; postmenopausal 1–8 ng/24hr; method- and laboratory-specific.
2-Hydroxyestrone reference range in this test: Premenopausal 5–30 ng/mg Cr; postmenopausal 3–15 ng/mg Cr. Method- and laboratory-specific.
Available exclusively to verified licensed healthcare practitioners. CLIA-certified laboratory results delivered to your secure portal.
Create Free Account