What is the reference range for 4-Hydroxyestrone?

The standard reference range for 4-Hydroxyestrone is Method-specific; typically <2 ng/mg creatinine in most reference populations.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure 4-Hydroxyestrone?

4-Hydroxyestrone is measured in 1 test on BiomarkersLabs.com, including Dried Urine GCMS Estrogen Hormone Metabolites.

Biomarker Reference · 4-OH-E1

What does the 4-Hydroxyestrone test measure?

Q: What is 4-Hydroxyestrone?

4-Hydroxyestrone is generated by cytochrome P450 1B1 hydroxylation at the C4 position. Unlike 2-OH metabolites, 4-OH catechols can form reactive quinones that bind DNA and generate oxidative adducts, a mechanism implicated in oestrogen-induced carcinogenesis in experimental models.

Q: Why is 4-Hydroxyestrone measured?

Elevated 4-OH-E1 is considered a biomarker of increased genotoxic risk. Functional and integrative practitioners monitor it as part of cancer-risk stratification, especially in women with family history or dense breast tissue, though prospective validation in clinical cohorts remains limited.

Q: Which tests measure 4-Hydroxyestrone?

4-Hydroxyestrone is measured in 1 test on BiomarkersLabs.com, including Dried Urine GCMS Estrogen Hormone Metabolites.

4-Hydroxyestrone (4-OH-E1) is a clinical biomarker used in female-hormones assessment. 4-Hydroxyestrone is generated by cytochrome P450 1B1 hydroxylation at the C4 position. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Method-specific; typically <2 ng/mg creatinine in most reference populations.
Units: ng/mg creatinine
Measured In: 1 test
Category: Female Hormones

Functional medicine optimalLower is generally preferred; specific thresholds and clinical actionability are contested and should be flagged as emerging rather than established.

What is 4-Hydroxyestrone?

4-Hydroxyestrone is generated by cytochrome P450 1B1 hydroxylation at the C4 position. Unlike 2-OH metabolites, 4-OH catechols can form reactive quinones that bind DNA and generate oxidative adducts, a mechanism implicated in oestrogen-induced carcinogenesis in experimental models.

Why is 4-Hydroxyestrone measured?

Elevated 4-OH-E1 is considered a biomarker of increased genotoxic risk. Functional and integrative practitioners monitor it as part of cancer-risk stratification, especially in women with family history or dense breast tissue, though prospective validation in clinical cohorts remains limited.

Reference ranges

Standard reference: Method-specific; typically <2 ng/mg creatinine in most reference populations.
Functional medicine optimal: Lower is generally preferred; specific thresholds and clinical actionability are contested and should be flagged as emerging rather than established.
Units: ng/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure 4-Hydroxyestrone

1 test on BiomarkersLabs.com include this biomarker.

BML-HRF-024Comprehensive

Dried Urine GCMS Estrogen Hormone Metabolites

4-Hydroxyestrone reference range in this test: Method-specific; typically <2 ng/mg creatinine in most reference populations.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

EstroneE15 tests EstradiolE25 tests EstriolE35 tests 2-Hydroxyestrone2-OH-E11 test 16α-Hydroxyestrone16α-OH-E11 test 2-Hydroxyestrone : 16α-Hydroxyestrone Ratio2:16α-OH-E11 test 2-Methoxyestrone2-MeOE11 test 4-Methoxyestrone4-MeOE11 test

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