Which tests measure Anti-Centromere B Antibody?

Anti-Centromere B Antibody is measured in 1 test on BiomarkersLabs.com, including ANA 11 Components (No ANA Screen).

Biomarker Reference · Anti-CENP-B

What does the Anti-Centromere B Antibody test measure?

Q: Why is Anti-Centromere B Antibody measured?

Anti-centromere B is the characteristic serological marker for limited cutaneous systemic sclerosis (lSSc), including CREST syndrome, with specificity approaching 98% for systemic sclerosis. Positive patients carry elevated risk of pulmonary arterial hypertension relative to anti-Scl-70-positive patients. Anti-centromere and anti-Scl-70 are mutually exclusive in the vast majority of cases, defining divergent SSc subsets.

Q: What is the reference range for Anti-Centromere B Antibody?

The standard reference range for Anti-Centromere B Antibody is <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Anti-Centromere B Antibody (Anti-CENP-B) is a clinical biomarker used in autoimmune-inflammation assessment. Centromere B (CENP-B) is a constitutive kinetochore protein of 80 kDa that binds to a specific 17-base pair sequence in centromeric satellite DNA and is essential for proper chromosome segregation during mitosis. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.
Units: AI (antibody index)
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNegative — positive result defines the limited cutaneous SSc subset and triggers PAH surveillance protocols.

What is Anti-Centromere B Antibody?

Centromere B (CENP-B) is a constitutive kinetochore protein of 80 kDa that binds to a specific 17-base pair sequence in centromeric satellite DNA and is essential for proper chromosome segregation during mitosis. Anti-CENP-B antibodies are the primary marker used clinically as a surrogate for anti-centromere reactivity and are detected by ELISA or line blot.

Why is Anti-Centromere B Antibody measured?

Anti-centromere B is the characteristic serological marker for limited cutaneous systemic sclerosis (lSSc), including CREST syndrome, with specificity approaching 98% for systemic sclerosis. Positive patients carry elevated risk of pulmonary arterial hypertension relative to anti-Scl-70-positive patients. Anti-centromere and anti-Scl-70 are mutually exclusive in the vast majority of cases, defining divergent SSc subsets.

Reference ranges

Standard reference: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.
Functional medicine optimal: Negative — positive result defines the limited cutaneous SSc subset and triggers PAH surveillance protocols.
Units: AI (antibody index)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-Centromere B Antibody

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-001Comprehensive

ANA 11 Components (No ANA Screen)

Anti-Centromere B Antibody reference range in this test: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Double-Stranded DNA Antibody (IgG)Anti-dsDNA IgG1 test Anti-Smith AntibodyAnti-Sm1 test Anti-U1 Ribonucleoprotein AntibodyAnti-RNP1 test Anti-SSA/Ro 60 kDa AntibodyAnti-Ro601 test Anti-SSA/Ro 52 kDa Antibody (TRIM21)Anti-Ro521 test Anti-SSB/La AntibodyAnti-La1 test Anti-Scl-70 (Topoisomerase I) AntibodyAnti-Scl-701 test Anti-Jo-1 (Histidyl-tRNA Synthetase) AntibodyAnti-Jo-11 test

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