What is the reference range for Anti-SSB/La Antibody?

The standard reference range for Anti-SSB/La Antibody is <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Anti-SSB/La Antibody?

Anti-SSB/La Antibody is measured in 1 test on BiomarkersLabs.com, including ANA 11 Components (No ANA Screen).

Biomarker Reference · Anti-La

What does the Anti-SSB/La Antibody test measure?

Q: What is Anti-SSB/La Antibody?

The La (SS-B) antigen is an RNA-binding phosphoprotein that associates with RNA polymerase III transcripts and plays a role in RNA processing and transcription termination. Anti-SSB/La antibodies arise through epitope spreading and are almost invariably present alongside concurrent anti-SSA/Ro positivity.

Q: Why is Anti-SSB/La Antibody measured?

Anti-SSB/La is highly associated with primary Sjögren's syndrome and is rarely present in the absence of anti-SSA/Ro. The co-occurrence of both anti-SSA and anti-SSB confers higher neonatal lupus risk than anti-SSA alone. Isolated anti-SSB without anti-SSA is clinically uncommon and warrants confirmatory repeat testing to exclude a false-positive result.

Q: Which tests measure Anti-SSB/La Antibody?

Anti-SSB/La Antibody is measured in 1 test on BiomarkersLabs.com, including ANA 11 Components (No ANA Screen).

Anti-SSB/La Antibody (Anti-La) is a clinical biomarker used in autoimmune-inflammation assessment. The La (SS-B) antigen is an RNA-binding phosphoprotein that associates with RNA polymerase III transcripts and plays a role in RNA processing and transcription termination. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.
Units: AI (antibody index)
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNegative — isolated positivity without anti-SSA should prompt confirmatory repeat testing before clinical decisions are based on the result.

What is Anti-SSB/La Antibody?

The La (SS-B) antigen is an RNA-binding phosphoprotein that associates with RNA polymerase III transcripts and plays a role in RNA processing and transcription termination. Anti-SSB/La antibodies arise through epitope spreading and are almost invariably present alongside concurrent anti-SSA/Ro positivity.

Why is Anti-SSB/La Antibody measured?

Anti-SSB/La is highly associated with primary Sjögren's syndrome and is rarely present in the absence of anti-SSA/Ro. The co-occurrence of both anti-SSA and anti-SSB confers higher neonatal lupus risk than anti-SSA alone. Isolated anti-SSB without anti-SSA is clinically uncommon and warrants confirmatory repeat testing to exclude a false-positive result.

Reference ranges

Standard reference: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.
Functional medicine optimal: Negative — isolated positivity without anti-SSA should prompt confirmatory repeat testing before clinical decisions are based on the result.
Units: AI (antibody index)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-SSB/La Antibody

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-001Comprehensive

ANA 11 Components (No ANA Screen)

Anti-SSB/La Antibody reference range in this test: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Double-Stranded DNA Antibody (IgG)Anti-dsDNA IgG1 test Anti-Smith AntibodyAnti-Sm1 test Anti-U1 Ribonucleoprotein AntibodyAnti-RNP1 test Anti-SSA/Ro 60 kDa AntibodyAnti-Ro601 test Anti-SSA/Ro 52 kDa Antibody (TRIM21)Anti-Ro521 test Anti-Scl-70 (Topoisomerase I) AntibodyAnti-Scl-701 test Anti-Jo-1 (Histidyl-tRNA Synthetase) AntibodyAnti-Jo-11 test Anti-Centromere B AntibodyAnti-CENP-B1 test

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