Which tests measure Anti-U1 Ribonucleoprotein Antibody?

Anti-U1 Ribonucleoprotein Antibody is measured in 1 test on BiomarkersLabs.com, including ANA 11 Components (No ANA Screen).

Biomarker Reference · Anti-RNP

What does the Anti-U1 Ribonucleoprotein Antibody test measure?

Q: Why is Anti-U1 Ribonucleoprotein Antibody measured?

High-titre anti-U1-RNP is the defining serological criterion for mixed connective tissue disease (MCTD), present in over 95% of cases. It is also found in SLE, systemic sclerosis, and overlap syndromes. Isolated high-titre anti-RNP without other CTD-specific antibodies should prompt clinical assessment specifically for MCTD.

Q: What is the reference range for Anti-U1 Ribonucleoprotein Antibody?

The standard reference range for Anti-U1 Ribonucleoprotein Antibody is <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Anti-U1 Ribonucleoprotein Antibody (Anti-RNP) is a clinical biomarker used in autoimmune-inflammation assessment. Anti-U1-RNP antibodies target the 70 kDa, A, and C protein components of the U1 small nuclear ribonucleoprotein complex involved in pre-mRNA splicing. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.
Units: AI (antibody index)
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNegative — high-titre positivity is the defining serological criterion for MCTD; no functional medicine grading applies.

What is Anti-U1 Ribonucleoprotein Antibody?

Anti-U1-RNP antibodies target the 70 kDa, A, and C protein components of the U1 small nuclear ribonucleoprotein complex involved in pre-mRNA splicing. They represent a distinct B-cell response from anti-Sm despite shared snRNP substrate and are present across multiple connective tissue disease diagnoses.

Why is Anti-U1 Ribonucleoprotein Antibody measured?

High-titre anti-U1-RNP is the defining serological criterion for mixed connective tissue disease (MCTD), present in over 95% of cases. It is also found in SLE, systemic sclerosis, and overlap syndromes. Isolated high-titre anti-RNP without other CTD-specific antibodies should prompt clinical assessment specifically for MCTD.

Reference ranges

Standard reference: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.
Functional medicine optimal: Negative — high-titre positivity is the defining serological criterion for MCTD; no functional medicine grading applies.
Units: AI (antibody index)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-U1 Ribonucleoprotein Antibody

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-001Comprehensive

ANA 11 Components (No ANA Screen)

Anti-U1 Ribonucleoprotein Antibody reference range in this test: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Double-Stranded DNA Antibody (IgG)Anti-dsDNA IgG1 test Anti-Smith AntibodyAnti-Sm1 test Anti-SSA/Ro 60 kDa AntibodyAnti-Ro601 test Anti-SSA/Ro 52 kDa Antibody (TRIM21)Anti-Ro521 test Anti-SSB/La AntibodyAnti-La1 test Anti-Scl-70 (Topoisomerase I) AntibodyAnti-Scl-701 test Anti-Jo-1 (Histidyl-tRNA Synthetase) AntibodyAnti-Jo-11 test Anti-Centromere B AntibodyAnti-CENP-B1 test

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