Which tests measure Anti-SSA/Ro 52 kDa Antibody (TRIM21)?

Anti-SSA/Ro 52 kDa Antibody (TRIM21) is measured in 1 test on BiomarkersLabs.com, including ANA 11 Components (No ANA Screen).

Biomarker Reference · Anti-Ro52

What does the Anti-SSA/Ro 52 kDa Antibody (TRIM21) test measure?

Q: Why is Anti-SSA/Ro 52 kDa Antibody (TRIM21) measured?

Anti-Ro52 is found in Sjögren's syndrome and SLE but has a distinct additional association with inflammatory myopathies, where it co-occurs with antisynthetase antibodies and is independently associated with interstitial lung disease. Isolated anti-Ro52 positivity without anti-Ro60 should prompt evaluation for myositis-spectrum disease alongside Sjögren's, not Sjögren's alone.

Q: What is the reference range for Anti-SSA/Ro 52 kDa Antibody (TRIM21)?

The standard reference range for Anti-SSA/Ro 52 kDa Antibody (TRIM21) is <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm whether Access Med Labs reports Ro52 as a discrete component or combines it with Ro60 as a single SSA result — panel composition varies between laboratories and this distinction has direct clinical implications.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Anti-SSA/Ro 52 kDa Antibody (TRIM21) (Anti-Ro52) is a clinical biomarker used in autoimmune-inflammation assessment. Ro52 (TRIM21) is an E3 ubiquitin ligase involved in innate immune regulation and is a structurally and functionally distinct protein from Ro60, despite the shared SSA designation. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm whether Access Med Labs reports Ro52 as a discrete component or combines it with Ro60 as a single SSA result — panel composition varies between laboratories and this distinction has direct clinical implications.
Units: AI (antibody index)
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNegative — isolated anti-Ro52 positivity has distinct clinical implications from anti-Ro60 and should not be interpreted interchangeably.

What is Anti-SSA/Ro 52 kDa Antibody (TRIM21)?

Ro52 (TRIM21) is an E3 ubiquitin ligase involved in innate immune regulation and is a structurally and functionally distinct protein from Ro60, despite the shared SSA designation. It is not an RNA-binding protein and is not part of the canonical Ro ribonucleoprotein particle, making the two SSA antigens immunologically non-redundant.

Why is Anti-SSA/Ro 52 kDa Antibody (TRIM21) measured?

Anti-Ro52 is found in Sjögren's syndrome and SLE but has a distinct additional association with inflammatory myopathies, where it co-occurs with antisynthetase antibodies and is independently associated with interstitial lung disease. Isolated anti-Ro52 positivity without anti-Ro60 should prompt evaluation for myositis-spectrum disease alongside Sjögren's, not Sjögren's alone.

Reference ranges

Standard reference: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm whether Access Med Labs reports Ro52 as a discrete component or combines it with Ro60 as a single SSA result — panel composition varies between laboratories and this distinction has direct clinical implications.
Functional medicine optimal: Negative — isolated anti-Ro52 positivity has distinct clinical implications from anti-Ro60 and should not be interpreted interchangeably.
Units: AI (antibody index)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-SSA/Ro 52 kDa Antibody (TRIM21)

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-001Comprehensive

ANA 11 Components (No ANA Screen)

Anti-SSA/Ro 52 kDa Antibody (TRIM21) reference range in this test: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm whether Access Med Labs reports Ro52 as a discrete component or combines it with Ro60 as a single SSA result — panel composition varies between laboratories and this distinction has direct clinical implications.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Double-Stranded DNA Antibody (IgG)Anti-dsDNA IgG1 test Anti-Smith AntibodyAnti-Sm1 test Anti-U1 Ribonucleoprotein AntibodyAnti-RNP1 test Anti-SSA/Ro 60 kDa AntibodyAnti-Ro601 test Anti-SSB/La AntibodyAnti-La1 test Anti-Scl-70 (Topoisomerase I) AntibodyAnti-Scl-701 test Anti-Jo-1 (Histidyl-tRNA Synthetase) AntibodyAnti-Jo-11 test Anti-Centromere B AntibodyAnti-CENP-B1 test

Order tests measuring Anti-SSA/Ro 52 kDa Antibody (TRIM21) for your patients

Available exclusively to verified licensed healthcare practitioners. CLIA-certified and IVDR-compliant laboratory results delivered to your secure portal.