Which tests measure Anti-Double-Stranded DNA Antibody (IgG)?

Anti-Double-Stranded DNA Antibody (IgG) is measured in 1 test on BiomarkersLabs.com, including ANA 11 Components (No ANA Screen).

Biomarker Reference · Anti-dsDNA IgG

What does the Anti-Double-Stranded DNA Antibody (IgG) test measure?

Q: Why is Anti-Double-Stranded DNA Antibody (IgG) measured?

Anti-dsDNA IgG is one of two autoantibodies included as a weighted domain in the 2019 EULAR/ACR SLE classification criteria. Rising titres correlate with lupus nephritis activity and can precede clinical flare, providing actionable serial monitoring data in established SLE in a way that most other CTD autoantibodies do not.

Q: What is the reference range for Anti-Double-Stranded DNA Antibody (IgG)?

The standard reference range for Anti-Double-Stranded DNA Antibody (IgG) is 15 IU/mL (positive) # REVIEWER FLAG: Confirm Access Med Labs cut-off values and borderline range — thresholds vary between assay platforms. WHO international standard IU/mL is the preferred unit; verify whether Access Med Labs reports in IU/mL or as an index value.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Anti-Double-Stranded DNA Antibody (IgG) (Anti-dsDNA IgG) is a clinical biomarker used in autoimmune-inflammation assessment. Anti-dsDNA antibodies arise from dysregulated B-cell tolerance and target the phosphodiester backbone of double-stranded DNA, forming pathogenic immune complexes that deposit in glomeruli and other tissues, driving complement activation and organ inflammation. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <10 IU/mL (negative); 10–15 IU/mL (borderline); >15 IU/mL (positive) # REVIEWER FLAG: Confirm Access Med Labs cut-off values and borderline range — thresholds vary between assay platforms. WHO international standard IU/mL is the preferred unit; verify whether Access Med Labs reports in IU/mL or as an index value.
Units: IU/mL
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNegative (<10 IU/mL) — rising titres in established SLE are clinically significant and correlate with nephritis flare risk; no functional medicine optimal range applies.

What is Anti-Double-Stranded DNA Antibody (IgG)?

Anti-dsDNA antibodies arise from dysregulated B-cell tolerance and target the phosphodiester backbone of double-stranded DNA, forming pathogenic immune complexes that deposit in glomeruli and other tissues, driving complement activation and organ inflammation. Titre levels fluctuate dynamically with lupus disease activity, distinguishing anti-dsDNA from most other panel components which remain stable once positive.

Why is Anti-Double-Stranded DNA Antibody (IgG) measured?

Anti-dsDNA IgG is one of two autoantibodies included as a weighted domain in the 2019 EULAR/ACR SLE classification criteria. Rising titres correlate with lupus nephritis activity and can precede clinical flare, providing actionable serial monitoring data in established SLE in a way that most other CTD autoantibodies do not.

Reference ranges

Standard reference: <10 IU/mL (negative); 10–15 IU/mL (borderline); >15 IU/mL (positive) # REVIEWER FLAG: Confirm Access Med Labs cut-off values and borderline range — thresholds vary between assay platforms. WHO international standard IU/mL is the preferred unit; verify whether Access Med Labs reports in IU/mL or as an index value.
Functional medicine optimal: Negative (<10 IU/mL) — rising titres in established SLE are clinically significant and correlate with nephritis flare risk; no functional medicine optimal range applies.
Units: IU/mL

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-Double-Stranded DNA Antibody (IgG)

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-001Comprehensive

ANA 11 Components (No ANA Screen)

Anti-Double-Stranded DNA Antibody (IgG) reference range in this test: <10 IU/mL (negative); 10–15 IU/mL (borderline); >15 IU/mL (positive) # REVIEWER FLAG: Confirm Access Med Labs cut-off values and borderline range — thresholds vary between assay platforms. WHO international standard IU/mL is the preferred unit; verify whether Access Med Labs reports in IU/mL or as an index value.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Smith AntibodyAnti-Sm1 test Anti-U1 Ribonucleoprotein AntibodyAnti-RNP1 test Anti-SSA/Ro 60 kDa AntibodyAnti-Ro601 test Anti-SSA/Ro 52 kDa Antibody (TRIM21)Anti-Ro521 test Anti-SSB/La AntibodyAnti-La1 test Anti-Scl-70 (Topoisomerase I) AntibodyAnti-Scl-701 test Anti-Jo-1 (Histidyl-tRNA Synthetase) AntibodyAnti-Jo-11 test Anti-Centromere B AntibodyAnti-CENP-B1 test

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