Which tests measure Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody?

Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody is measured in 1 test on BiomarkersLabs.com, including ANA 11 Components (No ANA Screen).

Biomarker Reference · Anti-Jo-1

What does the Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody test measure?

Q: Why is Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody measured?

Anti-Jo-1 is the defining autoantibody of antisynthetase syndrome — characterised by the clinical pentad of inflammatory myopathy, interstitial lung disease, inflammatory arthritis, mechanic's hands, and Raynaud's phenomenon. A positive result warrants pulmonary function testing and HRCT chest to screen for ILD, which is the primary driver of morbidity and mortality in this condition.

Q: What is the reference range for Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody?

The standard reference range for Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody is <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody (Anti-Jo-1) is a clinical biomarker used in autoimmune-inflammation assessment. Jo-1 antibodies target histidyl-tRNA synthetase (HRS), a cytoplasmic aminoacyl-tRNA synthetase responsible for charging histidine onto its cognate tRNA during protein synthesis. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.
Units: AI (antibody index)
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNegative — positive result requires dedicated ILD and myositis workup regardless of current symptom severity.

What is Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody?

Jo-1 antibodies target histidyl-tRNA synthetase (HRS), a cytoplasmic aminoacyl-tRNA synthetase responsible for charging histidine onto its cognate tRNA during protein synthesis. Anti-Jo-1 is the prototype and most prevalent of the antisynthetase antibodies, which as a class define antisynthetase syndrome.

Why is Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody measured?

Anti-Jo-1 is the defining autoantibody of antisynthetase syndrome — characterised by the clinical pentad of inflammatory myopathy, interstitial lung disease, inflammatory arthritis, mechanic's hands, and Raynaud's phenomenon. A positive result warrants pulmonary function testing and HRCT chest to screen for ILD, which is the primary driver of morbidity and mortality in this condition.

Reference ranges

Standard reference: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.
Functional medicine optimal: Negative — positive result requires dedicated ILD and myositis workup regardless of current symptom severity.
Units: AI (antibody index)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-001Comprehensive

ANA 11 Components (No ANA Screen)

Anti-Jo-1 (Histidyl-tRNA Synthetase) Antibody reference range in this test: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Double-Stranded DNA Antibody (IgG)Anti-dsDNA IgG1 test Anti-Smith AntibodyAnti-Sm1 test Anti-U1 Ribonucleoprotein AntibodyAnti-RNP1 test Anti-SSA/Ro 60 kDa AntibodyAnti-Ro601 test Anti-SSA/Ro 52 kDa Antibody (TRIM21)Anti-Ro521 test Anti-SSB/La AntibodyAnti-La1 test Anti-Scl-70 (Topoisomerase I) AntibodyAnti-Scl-701 test Anti-Centromere B AntibodyAnti-CENP-B1 test

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