Which tests measure Anti-Histone Antibody?

Anti-Histone Antibody is measured in 1 test on BiomarkersLabs.com, including ANA 11 Components (No ANA Screen).

Biomarker Reference · Anti-Histone

What does the Anti-Histone Antibody test measure?

Q: Why is Anti-Histone Antibody measured?

Anti-histone is present in over 95% of drug-induced lupus erythematosus (DILE) cases, making it the key discriminating marker when this diagnosis is considered. Causative agents include procainamide, hydralazine, minocycline, isoniazid, and TNF-alpha inhibitors. Anti-histone is also found in approximately 50–70% of idiopathic SLE — drug history is essential for interpretation and positivity alone cannot distinguish DILE from idiopathic SLE.

Q: What is the reference range for Anti-Histone Antibody?

The standard reference range for Anti-Histone Antibody is <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs — some platforms report in units/mL.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Anti-Histone Antibody (Anti-Histone) is a clinical biomarker used in autoimmune-inflammation assessment. Histone antibodies target the core nucleosomal histone proteins H2A, H2B, H3, and H4, as well as linker histone H1, generated through mechanisms including impaired apoptotic clearance of nucleosomal material and drug-induced disruption of central tolerance. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs — some platforms report in units/mL.
Units: AI (antibody index)
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNegative — positive result requires comprehensive medication review to assess for drug-induced lupus as a primary differential before attributing the result to idiopathic SLE.

What is Anti-Histone Antibody?

Histone antibodies target the core nucleosomal histone proteins H2A, H2B, H3, and H4, as well as linker histone H1, generated through mechanisms including impaired apoptotic clearance of nucleosomal material and drug-induced disruption of central tolerance.

Why is Anti-Histone Antibody measured?

Anti-histone is present in over 95% of drug-induced lupus erythematosus (DILE) cases, making it the key discriminating marker when this diagnosis is considered. Causative agents include procainamide, hydralazine, minocycline, isoniazid, and TNF-alpha inhibitors. Anti-histone is also found in approximately 50–70% of idiopathic SLE — drug history is essential for interpretation and positivity alone cannot distinguish DILE from idiopathic SLE.

Reference ranges

Standard reference: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs — some platforms report in units/mL.
Functional medicine optimal: Negative — positive result requires comprehensive medication review to assess for drug-induced lupus as a primary differential before attributing the result to idiopathic SLE.
Units: AI (antibody index)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anti-Histone Antibody

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-001Comprehensive

ANA 11 Components (No ANA Screen)

Anti-Histone Antibody reference range in this test: <1.0 AI (negative); ≥1.0 AI (positive) # REVIEWER FLAG: Confirm cut-off and reporting format with Access Med Labs — some platforms report in units/mL.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Double-Stranded DNA Antibody (IgG)Anti-dsDNA IgG1 test Anti-Smith AntibodyAnti-Sm1 test Anti-U1 Ribonucleoprotein AntibodyAnti-RNP1 test Anti-SSA/Ro 60 kDa AntibodyAnti-Ro601 test Anti-SSA/Ro 52 kDa Antibody (TRIM21)Anti-Ro521 test Anti-SSB/La AntibodyAnti-La1 test Anti-Scl-70 (Topoisomerase I) AntibodyAnti-Scl-701 test Anti-Jo-1 (Histidyl-tRNA Synthetase) AntibodyAnti-Jo-11 test

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