Biomarker Reference · BUN:Cr
BUN:Creatinine Ratio (BUN:Cr) is a clinical biomarker used in metabolic-diabetes assessment. The BUN:creatinine ratio compares two nitrogenous waste products with different renal handling. It is measured in 3 laboratory tests on BiomarkersLabs.com.
The BUN:creatinine ratio compares two nitrogenous waste products with different renal handling. Creatinine is filtered and minimally reabsorbed, so it tracks GFR closely. Urea is filtered and passively reabsorbed, particularly in volume-depleted states when tubular flow slows. A high ratio therefore indicates disproportionate urea retention, typically from reduced renal perfusion.
A ratio above 20:1 suggests pre-renal azotaemia (volume depletion, heart failure, renal artery stenosis) or increased urea production (gastrointestinal bleeding, high protein intake, catabolic illness). A ratio below 10:1 can be seen with overhydration, liver disease (reduced urea synthesis), or a low-protein diet. Intrinsic renal disease typically preserves the ratio near the reference range, so the ratio helps distinguish pre-renal from intrinsic acute kidney injury.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
3 tests on BiomarkersLabs.com include this biomarker.
BUN:Creatinine Ratio reference range in this test: Approximately 10:1 to 20:1 (using mg/dL units).
BUN:Creatinine Ratio reference range in this test: Approximately 10:1 to 20:1 in conventional units (mg/dL).
BUN:Creatinine Ratio reference range in this test: 10–20 (dimensionless); calculated as BUN (mg/dL) ÷ creatinine (mg/dL).
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