Biomarker Reference · Cl
Chloride (Cl) is a clinical biomarker used in metabolic-diabetes assessment. Chloride is the major extracellular anion, accompanying sodium to maintain electrical neutrality and osmotic balance. It is measured in 6 laboratory tests on BiomarkersLabs.com.
Chloride is the major extracellular anion, accompanying sodium to maintain electrical neutrality and osmotic balance. It moves in and out of cells via exchangers, particularly the bicarbonate–chloride exchanger in red cells and renal tubules, linking chloride to acid–base regulation. Plasma chloride is driven by sodium concentration, water balance, and bicarbonate levels.
Hypochloraemia (<98 mmol/L) is seen with vomiting (loss of HCl), diuretic use, and metabolic alkalosis. Hyperchloraemia (>107 mmol/L) accompanies metabolic acidosis (normal-anion-gap or hyperchloraemic acidosis), often from diarrhoea or renal tubular acidosis. The anion gap—calculated as [Na − (Cl + HCO₃)]—is central to acid–base diagnosis and uses chloride as one of its three inputs.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
6 tests on BiomarkersLabs.com include this biomarker.
Chloride reference range in this test: Approximately 98–107 mmol/L.
Chloride reference range in this test: Approximately 98–107 mmol/L; assay-specific.
Chloride reference range in this test: 96–106 mmol/L; laboratory-specific.
Chloride reference range in this test: 98–107 mmol/L; laboratory-specific.
Chloride reference range in this test: 96–106 mmol/L, assay-specific.
Chloride reference range in this test: 98–107 mmol/L (laboratory-specific).
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