Which tests measure GABA (γ-Aminobutyric Acid), 24-Hour Urine?

GABA (γ-Aminobutyric Acid), 24-Hour Urine is measured in 1 test on BiomarkersLabs.com, including NeuroBasic Profile — 24 Hour Urine.

Biomarker Reference · GABA

What does the GABA (γ-Aminobutyric Acid), 24-Hour Urine test measure?

Q: What is the reference range for GABA (γ-Aminobutyric Acid), 24-Hour Urine?

The standard reference range for GABA (γ-Aminobutyric Acid), 24-Hour Urine is 1.5–6.8 µmol/24h # REVIEWER FLAG: Confirm Doctor's Data reference range — GABA urinary reference intervals are highly platform-specific and not standardised across laboratory networks.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

GABA (γ-Aminobutyric Acid), 24-Hour Urine (GABA) is a clinical biomarker used in neurological-mental-health assessment. GABA is the primary inhibitory neurotransmitter of the central nervous system, synthesised from glutamate by glutamic acid decarboxylase (GAD) — a reaction requiring pyridoxal-5-phosphate (vitamin B6) as an essential cofactor. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: 1.5–6.8 µmol/24h # REVIEWER FLAG: Confirm Doctor's Data reference range — GABA urinary reference intervals are highly platform-specific and not standardised across laboratory networks.
Units: µmol/24h
Measured In: 1 test
Category: Neurological

Functional medicine optimalNo standardised functional medicine optimal range; balance relative to glutamate is considered as important as absolute value. # REVIEWER FLAG: Confirm Doctor's Data documentation and whether a GABA:glutamate ratio is reported.

What is GABA (γ-Aminobutyric Acid), 24-Hour Urine?

GABA is the primary inhibitory neurotransmitter of the central nervous system, synthesised from glutamate by glutamic acid decarboxylase (GAD) — a reaction requiring pyridoxal-5-phosphate (vitamin B6) as an essential cofactor. Urinary GABA is derived from peripheral sources including the pancreas, gastrointestinal tract, and renal tubular cells; central GABAergic neurons do not contribute measurably to urinary output due to blood-brain barrier exclusion.

Why is GABA (γ-Aminobutyric Acid), 24-Hour Urine measured?

In functional medicine, urinary GABA is used alongside urinary glutamate as a proxy for the balance between inhibitory and excitatory neurotransmitter tone. Reduced GABA output is associated with anxiety, sleep disturbance, and seizure susceptibility in integrative clinical frameworks and guides supplementation with GABA precursors, magnesium, taurine, and B6. Practitioners must note that peripheral urinary GABA does not directly reflect central GABAergic inhibitory activity — the blood-brain barrier prevents GABA from entering the CNS when supplemented orally, complicating direct interpretation.

Reference ranges

Standard reference: 1.5–6.8 µmol/24h # REVIEWER FLAG: Confirm Doctor's Data reference range — GABA urinary reference intervals are highly platform-specific and not standardised across laboratory networks.
Functional medicine optimal: No standardised functional medicine optimal range; balance relative to glutamate is considered as important as absolute value. # REVIEWER FLAG: Confirm Doctor's Data documentation and whether a GABA:glutamate ratio is reported.
Units: µmol/24h

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure GABA (γ-Aminobutyric Acid), 24-Hour Urine

1 test on BiomarkersLabs.com include this biomarker.

BML-NMH-001Comprehensive

NeuroBasic Profile — 24 Hour Urine

GABA (γ-Aminobutyric Acid), 24-Hour Urine reference range in this test: 1.5–6.8 µmol/24h # REVIEWER FLAG: Confirm Doctor's Data reference range — GABA urinary reference intervals are highly platform-specific and not standardised across laboratory networks.

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