Which tests measure Histamine, 24-Hour Urine?

Histamine, 24-Hour Urine is measured in 1 test on BiomarkersLabs.com, including NeuroBasic Profile — 24 Hour Urine.

Biomarker Reference · Hist

What does the Histamine, 24-Hour Urine test measure?

Q: What is the reference range for Histamine, 24-Hour Urine?

The standard reference range for Histamine, 24-Hour Urine is 10–130 µg/24h # REVIEWER FLAG: Confirm Doctor's Data reference range for urinary histamine — values are highly platform-specific and dietary histamine loading significantly affects results.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Histamine, 24-Hour Urine (Hist) is a clinical biomarker used in neurological-mental-health assessment. Histamine is synthesised from L-histidine by histidine decarboxylase in mast cells, basophils, enterochromaffin-like cells of the gastric mucosa, and intestinal bacteria. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: 10–130 µg/24h # REVIEWER FLAG: Confirm Doctor's Data reference range for urinary histamine — values are highly platform-specific and dietary histamine loading significantly affects results.
Units: µg/24h, nmol/24h
Measured In: 1 test
Category: Neurological

Functional medicine optimalNo standardised functional medicine optimal range; dietary and DAO enzyme status must be considered alongside absolute value. # REVIEWER FLAG: Confirm Doctor's Data documentation.

What is Histamine, 24-Hour Urine?

Histamine is synthesised from L-histidine by histidine decarboxylase in mast cells, basophils, enterochromaffin-like cells of the gastric mucosa, and intestinal bacteria. Urinary histamine reflects peripheral histamine production and catabolism — the gut microbiome and dietary histamine load are the dominant determinants of urinary output, with central histaminergic neurotransmission contributing minimally.

Why is Histamine, 24-Hour Urine measured?

Urinary histamine is included in the NeuroBasic Profile as a neuroactive amine with relevance to neuroinflammation, sleep-wake regulation, and immune activation. In functional medicine, elevated urinary histamine is interpreted in the context of histamine intolerance, mast cell activation, and gut dysbiosis. Dietary high-histamine foods and DAO (diamine oxidase) deficiency are primary drivers of elevated urinary histamine and must be considered in result interpretation.

Reference ranges

Standard reference: 10–130 µg/24h # REVIEWER FLAG: Confirm Doctor's Data reference range for urinary histamine — values are highly platform-specific and dietary histamine loading significantly affects results.
Functional medicine optimal: No standardised functional medicine optimal range; dietary and DAO enzyme status must be considered alongside absolute value. # REVIEWER FLAG: Confirm Doctor's Data documentation.
Units: µg/24h, nmol/24h

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Histamine, 24-Hour Urine

1 test on BiomarkersLabs.com include this biomarker.

BML-NMH-001Comprehensive

NeuroBasic Profile — 24 Hour Urine

Histamine, 24-Hour Urine reference range in this test: 10–130 µg/24h # REVIEWER FLAG: Confirm Doctor's Data reference range for urinary histamine — values are highly platform-specific and dietary histamine loading significantly affects results.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Serotonin (5-Hydroxytryptamine), 24-Hour Urine5-HT1 test Dopamine, 24-Hour UrineDA1 test Norepinephrine (Noradrenaline), 24-Hour UrineNE1 test Epinephrine (Adrenaline), 24-Hour UrineEPI1 test GABA (γ-Aminobutyric Acid), 24-Hour UrineGABA1 test Glutamate, 24-Hour UrineGlu1 test Glycine, 24-Hour UrineGly1 test β-Phenylethylamine (PEA), 24-Hour UrinePEA1 test

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