Which tests measure β-Phenylethylamine (PEA), 24-Hour Urine?

β-Phenylethylamine (PEA), 24-Hour Urine is measured in 1 test on BiomarkersLabs.com, including NeuroBasic Profile — 24 Hour Urine.

Biomarker Reference · PEA

What does the β-Phenylethylamine (PEA), 24-Hour Urine test measure?

Q: What is the reference range for β-Phenylethylamine (PEA), 24-Hour Urine?

The standard reference range for β-Phenylethylamine (PEA), 24-Hour Urine is # REVIEWER FLAG: Confirm Doctor's Data reference range for urinary PEA — PEA is present at trace concentrations in urine and reference intervals vary significantly by assay platform and detection method.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

β-Phenylethylamine (PEA), 24-Hour Urine (PEA) is a clinical biomarker used in neurological-mental-health assessment. β-Phenylethylamine is a trace amine synthesised from L-phenylalanine by aromatic L-amino acid decarboxylase. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: # REVIEWER FLAG: Confirm Doctor's Data reference range for urinary PEA — PEA is present at trace concentrations in urine and reference intervals vary significantly by assay platform and detection method.
Units: µg/24h, nmol/24h
Measured In: 1 test
Category: Neurological

Functional medicine optimalNo standardised functional medicine optimal range; interpretive frameworks vary between practitioners. # REVIEWER FLAG: Confirm Doctor's Data documentation.

What is β-Phenylethylamine (PEA), 24-Hour Urine?

β-Phenylethylamine is a trace amine synthesised from L-phenylalanine by aromatic L-amino acid decarboxylase. It acts as an endogenous neuromodulator and trace amine-associated receptor 1 (TAAR1) agonist, stimulating monoamine release and synaptic dopamine availability. PEA has an extremely short half-life (minutes) due to rapid MAO-B catabolism to phenylacetic acid, making urinary levels a reflection of both synthesis rate and MAO-B activity.

Why is β-Phenylethylamine (PEA), 24-Hour Urine measured?

Urinary PEA is assessed in functional medicine as a marker of endogenous trace amine activity, with reduced levels associated with depression, attention dysregulation, and motivational impairment in integrative frameworks. Elevated PEA has been associated with schizophrenia spectrum conditions in research contexts. Phenylacetic acid (the primary PEA metabolite) is sometimes measured alongside PEA to assess the synthesis-to-catabolism ratio. # REVIEWER FLAG: PEA clinical interpretation has a limited mainstream evidence base — reviewer to assess whether interpretive claims require additional caveating.

Reference ranges

Standard reference: # REVIEWER FLAG: Confirm Doctor's Data reference range for urinary PEA — PEA is present at trace concentrations in urine and reference intervals vary significantly by assay platform and detection method.
Functional medicine optimal: No standardised functional medicine optimal range; interpretive frameworks vary between practitioners. # REVIEWER FLAG: Confirm Doctor's Data documentation.
Units: µg/24h, nmol/24h

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure β-Phenylethylamine (PEA), 24-Hour Urine

1 test on BiomarkersLabs.com include this biomarker.

BML-NMH-001Comprehensive

NeuroBasic Profile — 24 Hour Urine

β-Phenylethylamine (PEA), 24-Hour Urine reference range in this test: # REVIEWER FLAG: Confirm Doctor's Data reference range for urinary PEA — PEA is present at trace concentrations in urine and reference intervals vary significantly by assay platform and detection method.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Serotonin (5-Hydroxytryptamine), 24-Hour Urine5-HT1 test Dopamine, 24-Hour UrineDA1 test Norepinephrine (Noradrenaline), 24-Hour UrineNE1 test Epinephrine (Adrenaline), 24-Hour UrineEPI1 test GABA (γ-Aminobutyric Acid), 24-Hour UrineGABA1 test Glutamate, 24-Hour UrineGlu1 test Glycine, 24-Hour UrineGly1 test Histamine, 24-Hour UrineHist1 test

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