Which tests measure Norepinephrine (Noradrenaline), 24-Hour Urine?

Norepinephrine (Noradrenaline), 24-Hour Urine is measured in 1 test on BiomarkersLabs.com, including NeuroBasic Profile — 24 Hour Urine.

Biomarker Reference · NE

What does the Norepinephrine (Noradrenaline), 24-Hour Urine test measure?

Q: What is the reference range for Norepinephrine (Noradrenaline), 24-Hour Urine?

The standard reference range for Norepinephrine (Noradrenaline), 24-Hour Urine is 15–100 µg/24h # REVIEWER FLAG: Confirm Doctor's Data reference range — norepinephrine reference intervals vary by age and are sensitive to pre-analytical conditions.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Norepinephrine (Noradrenaline), 24-Hour Urine (NE) is a clinical biomarker used in neurological-mental-health assessment. Norepinephrine is synthesised from dopamine by dopamine β-hydroxylase within sympathetic nerve terminals and the adrenal medulla. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: 15–100 µg/24h # REVIEWER FLAG: Confirm Doctor's Data reference range — norepinephrine reference intervals vary by age and are sensitive to pre-analytical conditions.
Units: µg/24h, nmol/24h
Measured In: 1 test
Category: Neurological

Functional medicine optimalNo standardised functional medicine optimal range; mid-reference range is generally targeted. # REVIEWER FLAG: Confirm Doctor's Data guidance.

What is Norepinephrine (Noradrenaline), 24-Hour Urine?

Norepinephrine is synthesised from dopamine by dopamine β-hydroxylase within sympathetic nerve terminals and the adrenal medulla. Urinary norepinephrine derives predominantly from peripheral sympathetic nervous system spillover into the circulation and renal excretion; central noradrenergic neurons contribute minimally to urinary output. It is the primary catecholamine of sympathetic fight-or-flight activation and is catabolised by MAO and COMT to normetanephrine and vanillylmandelic acid (VMA).

Why is Norepinephrine (Noradrenaline), 24-Hour Urine measured?

In functional medicine, urinary norepinephrine is assessed alongside epinephrine as an indicator of sympathetic nervous system tone and adrenal-sympathetic output, particularly in the context of chronic stress, dysautonomia, and HPA axis dysregulation. Markedly elevated levels warrant clinical exclusion of catecholamine-secreting tumours before functional interpretations are applied. Reduced levels in the context of chronic fatigue are interpreted as sympathoadrenal depletion, guiding precursor support.

Reference ranges

Standard reference: 15–100 µg/24h # REVIEWER FLAG: Confirm Doctor's Data reference range — norepinephrine reference intervals vary by age and are sensitive to pre-analytical conditions.
Functional medicine optimal: No standardised functional medicine optimal range; mid-reference range is generally targeted. # REVIEWER FLAG: Confirm Doctor's Data guidance.
Units: µg/24h, nmol/24h

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Norepinephrine (Noradrenaline), 24-Hour Urine

1 test on BiomarkersLabs.com include this biomarker.

BML-NMH-001Comprehensive

NeuroBasic Profile — 24 Hour Urine

Norepinephrine (Noradrenaline), 24-Hour Urine reference range in this test: 15–100 µg/24h # REVIEWER FLAG: Confirm Doctor's Data reference range — norepinephrine reference intervals vary by age and are sensitive to pre-analytical conditions.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Serotonin (5-Hydroxytryptamine), 24-Hour Urine5-HT1 test Dopamine, 24-Hour UrineDA1 test Epinephrine (Adrenaline), 24-Hour UrineEPI1 test GABA (γ-Aminobutyric Acid), 24-Hour UrineGABA1 test Glutamate, 24-Hour UrineGlu1 test Glycine, 24-Hour UrineGly1 test β-Phenylethylamine (PEA), 24-Hour UrinePEA1 test Histamine, 24-Hour UrineHist1 test

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